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Table 4 Predictive power of models with established health utilization predictors without and with SNPs: results of the 10-fold cross validation

From: Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study

Statistical evaluation criteria Annual outpatient visits Hospitalization Annual inpatient days
Median (Nagelkerke R2)    
 Model 2 22.62 1.61 0.0175
 Model 2 + PNPLA3 rs738409 22.96 1.74 0.0138
 Model 2 + TM6SF2 rs58542926 20.33 1.56 0.0218
 Model 2 + PNPLA3 rs738409 + TM6SF2 rs58542926 22.73 1.99 0.0268
Median (root mean squared error)   
 Model 2 8.70   8.111
 Model 2 + PNPLA3 rs738409 8.78   7.121
 Model 2 + TM6SF2 rs58542926 8.69   7.422
 Model 2 + PNPLA3 rs738409 + TM6SF2 rs58542926 8.68   7.174
Median (absolute prediction error)   
 Model 2 5.89   3.605
 Model 2 + PNPLA3 rs738409 5.97   3.548
 Model 2 + TM6SF2 rs58542926 6.01   3.565
 Model 2 + PNPLA3 rs738409 + TM6SF2 rs58542926 6.07   3.594
Area under ROC curve (p-value for comparison to model 2)  
 Model 2   0.605  
 Model 2 + PNPLA3 rs738409   0.605 (0.846)  
 Model 2 + TM6SF2 rs58542926   0.606 (0.868)  
 Model 2 + PNPLA3 rs738409 + TM6SF2 rs58542926   0.606 (0.965)  
  1. Model 2: age, sex, school education, income, alcohol intake, smoking status, eGFR, Functional Comorbidity Index
  2. ROC receiver operating characteristic