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Table 1 Characteristics of study participants by PNPLA3 rs738409 and TM6SF2 rs58542926

From: Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study

 

PNPLA3 rs738409

TM6SF2 rs58542926

 

CC

CG

GG

CC

CT

TT

N (%)

2238 (59.6 %)

1347 (35.8 %)

173 (4.6 %)

3471 (80.6 %)

580 (13.5 %)

28 (0.7 %)

Annual number of outpatient visitsa

7.5 (2.5)

7.5 (3.5)

7.5 (2.6)

4.9 (2.2)

7.3 (2.6)

7.9 (2.5)*

Hospitalization during the last year, %

14.1

14.2

19.7*

7.4

13.7

14.6

Annual number of inpatient days among subjects with hospitalization during the last year, daysa

9.7 (2.6)

9.7 (2.3)

10.6 (2.5)*

6.9 (1.2)

9.6 (2.5)

11.1 (2.5)**

Age, years

49.91 (16.28)

49.40 (16.58)

50.00 (15.83)

49.3 (16.2)

48.7 (16.5)

47.4 (16.1)

Female, %

50.7

50.6

56.7*

50.1

54.7

74.1

School education (<10 years), %

39.1

37.7

39.1

38.4

40.3

33.3*

Equivalent household income, €a

852 (1.7)

833 (1.8)

879 (1.7)

852 (1.7)

807 (1.8)

929 (1.6)

Alcohol intake, g/da

7.3 (3.5)

7.5 (3.4)

5.9 (2.5)**

7.5 (3.5)

6.9 (3.5)

5.1 (3.9)

Regular smoking, %

29.7

32.3

28.3

30.4

31.3

25.9

Body mass index, kg/m2

27.3 (4.8)

27.1 (4.8)

26.9 (4.8)

27.3 (4.5)

27.3 (4.8)

26.2 (4.3)

Obesity, %

26.8

24.1

22.0

25.3

28.1

14.8

Waist circumference, cm

90.0 (14.0)

88.4 (13.8)**

87.3 (13.3)**

89.2 (13.9)

89.2 (14.2)

84.4 (13.1)

Systolic blood pressure, mmHg

135.6 (20.7)

135.6 (20.7)

136.2 (20.8)

132.4 (18.5)

136.0 (21.2)

134.6 (20.8)

Hypertension, %

51.9

52.8

52.6

37.0

52.9

49.1

Ferritin, μg/la

68.4 (2.7)

68.6 (2.6)

61.56 (2.58)

68.2 (2.6)

68.5 (2.7)

66.6 (3.0)

Hepatic steatosis, %

27.4

31.9**

39.9**

28.4

36.3**

44.4*

Increased ALT (>75th percentile), %

17.9

22.7**

28.3**

19.4

24.2*

29.6

GFR, ml.min.1.73 m2

79.5 (15.1)

80.0 (15.1)

79.8 (15.1)

79.5 (15.1)

80.9 (14.8)

78.8 (11.1)

High-density lipoprotein cholesterol,

1.45 (0.45)

1.46 (0.43)

1.49 (0.43)

1.45 (0.44)

1.48 (0.43)

1.50 (0.39)

Low-density cholesterol, mmol/l

3.59 (1.18)

3.54 (1.13)

3.54 (1.25)

3.59 (1.25)

3.50 (1.10)*

2.75 (1.27)**

Total cholesterol,

5.80 (1.28)

5.72 (1.19)

5.76 (1.32)

5.79 (1.25)

5.69 (1.22)**

4.82 (1.43)**

Dyslipidemia (TC/HDL-C ratio ≥ 5), %

27.8

25.8

24.3

27.6

24.0

14.8

triglycerides

1.91 (1.57)

1.80 (1.36)

1.78 (1.31)

1.89 (1.46)

1.74 (1.62)**

1.34 (1.53)**

Serum glucose

5.70 (1.87)

5.62 (1.67)

5.53 (1.76)

5.66 (1.81)

5.70 (1.81)

5.45 (1.00)

HbA1c, %

5.45 (0.97)

5.42 (0.88)

5.34 (0.84)

5.44 (0.92)

5.42 (0.99)

5.38 (0.49)

Diabetes, %

8.0

7.6

6.9

7.7

8.6

7.4

Upper gastrointestinal disease (ulcer, hernia, reflux), %

1.6

2.1

1.7

1.7

2.1

3.7

Myocardial infarction, %

3.4

3.3

3.5

3.3

3.4

3.9

Angina pectoris, %

5.0

3.4*

1.7*

3.9

5.8*

7.4

Congestive heart failure, %

12.51

10.62

14.45

22.2

12.0

11.1

Arthritis

7.2

7.3

11.6*

7.4

7.7

11.1

Osteoporosis

4.7

4.3

4.1

4.5

4.9

0

Chronic obstructive pulmonary disease, %

6.1

5.0

4.6

5.6

5.4

14.8

Multiple sclerosis or Parkinson’s disease, %

0.5

0.2

0

0.4

0.2

0

Stroke or TIA, %

2.3

1.6

1.7

2.1

1.7

0

Peripheral vascular disease, %

1.4

1.0

0.6

1.4

0

0

Degenerative disc disease, %

37.2

35.0

38.2

36.6

35.4

40.7

Anxiety, %

23.5

22.9

22.0

23.2

23.0

33.3

Depression, %

12.4

12.8

17.9*

12.6

13.9

14.8

Functional Comorbidity Indexa

1.6 (1.7)

1.6 (1.6)

1.7 (1.7)

1.6 (1.6)

1.6 (1.6)

1.7 (1.6)

  1. Entries are mean (SD) or % unless indicated differently
  2. GFR glomerular filtration rate, TC total cholesterol; HDL High-density lipoprotein cholesterol
  3. aGeometric mean (geometric SD)
  4. *p < .05
  5. **p < .01 for comparisons with CC-allele from t-test (continuous variables) or Fisher’s exact test (categorical variables)