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Table 1 Model parameters informed by results from the EXPEDITE study (published [11] and unpublished data)

From: Reduction in resource use with the misoprostol vaginal insert vs the dinoprostone vaginal insert for labour induction: a model-based analysis from a United Kingdom healthcare perspective

Model parameter DVI (n = 680) MVI (n = 678)
Clinical efficacy (published [11] and unpublished observations)
Median time to vaginal delivery per patient (hours) [11] 32.8 21.5
 Mean time to vaginal delivery per patient (hours) 25.2 18.2
 Proportion of women achieving vaginal delivery within 12 h (%) 10 21
 Proportion of women achieving vaginal delivery within 24 h (%) 36 56
 Proportion of women delivered by caesarean section due to a lack of efficacy (%) 2 1
Safety (unpublished observations)
 Total adverse events (%) [11] 2.6 % 10.0 %
 Uterine tachysystole without fetal heart rate involvement (requiring treatment) (%) 0.6 % 1.9 %
 Uterine tachysystole with fetal heart rate involvement (late decelerations, bradycardia, or prolonged decelerations) (%) 1.2 % 6.0 %
 Postpartum haemorrhage (%) 0.1 % 0.0 %
 Meconium-stained liquor (%) 0.6 % 1.2 %
 NICU admission (%) 0.1 % 0.6 %
 Low Apgar score (%) 0.0 % 0.1 %
 Uterine rupture 0.0 % 0.1 %
 Neonatal acidosis (%) 0.0 % 0.1 %