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Table 1 Model input parameters. Parameters used for intended and typical practice models

From: Cost-effectiveness of using the Cervex-Brush (broom) compared to the elongated spatula for collection of conventional cervical cytology samples within a high-burden HIV setting: a model-based analysis

Parameter

Mean

CI 95 %

Distribution

Source

  

p5

p95

  

Women tested (annual count)

723,829

583,056

869,393

Normal

NHLS database

Presence of endocervical cells broom vs spatula, odds ratio

1.57

1.44

1.70

Normal

[7]

Probability of detection of atypia/dyskaryosis in smears with enodcervical cells vs those without, odds ratio

1.89

1.80

1.98

Normal

[7]

Probability of detection of severe atypia/dyskaryosis in smears with enodcervical cells vs those without, odds ratio

2.46

1.75

3.17

Normal

[7]

HIV-infected (%)

51

40

64

Binomial

NHLS database

HIV-infected women tested (annual count)

372,340

261,707

493,988

Normal

Calculated

Abnormal Pap smear (% of all smears)

73

71

75

Binomial

[9]

HSIL (% of all smears)

31

29

33

Binomial

[9]

LSIL (% of all smears)

37

35

39

Binomial

[9]

ASC-US (% of all smears)

5

4

6

Binomial

[9]

Endocervical cells present, spatula (% of all smears)

53

52

54

Binomial

NHLS database

Endocervical cells present, broom (% of all smears)

83

76

90

Binomial

Calculated

Sensitivity (%, if endocervical cells present)

76

72

80

Binomial

[9]

Sensitivity (%, if no endocervical cells present)

40

35

45

Binomial

Calculated

Sensitivity HSIL (%, if no endocervical cells present)

32

23

44

Binomial

Calculated

Repeat Pap smear done (% of patients)

90

85

95

Binomial

Assumption

Smear satisfactory for evaluation (% of all smears)

98

98

99

Binomial

NHLS database

Specificity (%)

84

81

87

Binomial

[9]

Lost to follow-up (% of patients)

8

6

10

Binomial

[10]