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Table 3 Segmented regression analysis on the monthly ACEIs prescription proportion in the 13 UK regions

From: The impact of the ‘Better Care Better Value’ prescribing policy on the utilisation of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for treating hypertension in the UK primary care setting: longitudinal quasi-experimental design

Regions

β1(a)

β2(b)

β3(c)

β4(d)

β5(e)

β6(f)

β7(g)

High baseline ACEIs prescription proportion (>74 %)

  North East

−0.12 (−0.13, −0.11)

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0.04 (0.02, 0.06)

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  South East

−0.06 (−0.70, −0.05)

−0.31 (−0.7, −0.07)

0.02 (0.01, 0.04)

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  Wales

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  East Midlands

−0.03 (−0.04, −0.16)

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−0.64 (−1.1, −0.20)

0.16 (0.13, 0.19)

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Intermediate baseline ACEIs prescription proportion (65 %-74 %)

  Yorkshire and the Humber

−0.08 (−0.09, −0.06)

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0.20 (0.14, 0.24)

−1.80 (−0.26,-0.9)

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  East of England

−0.08 (−0.70, −0.05)

−0.40 (−0.7, −0.05)

0.02 (0.04, 0.03)

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  South Central

−0.01 (−0.2, −0.002)

−0.60 (−0.9, −0.40)

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−0.47 (−0.7, −0.20)

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  Scotland

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0.06 (0.04, 0.08)

−0.49 (−0.80, −0.10)

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  West Midlands

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−0.03 (−0.04, −0.02)

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  North West

0.01 (0.02, 0.018)

−0.57 (−0.8, −0.33)

0.04 (0.03, 0.05)

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  London

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0.40 (0.20, 0.60)

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0.04 (0.03, 0.05)

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Low baseline ACEIs prescription proportion (<65 %)

  South East Coast

0.013 (0.004, 0.02)

−0.42 (−0.7, −0.20)

−0.02 (−0.03,-0.002)

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  Northern Ireland

0.06 (0.05, 0.08)

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0.06 (0.02, 0.09)

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  1. Regression coefficients (95 % confidence intervals) for the final model (the most parsimonious models); (a)baseline trend; (b)level change following BCBV policy; (c)trend change following BCBV policy; (d)level change following generic losartan availability; (e)trend change following generic losartan availability; (f)level change following generic perindopril availability; (g)trend change following generic perindopril availability; −--: indicates insignificant estimates at 0.05 level, after stepwise backward elimination; ACEIs: Angiotensin converting enzyme inhibitors