Table 1 Selected effect size parameters used in the model (greater detail and full list provided in Additional file 2)
From: Cancer care coordinators in stage III colon cancer: a cost-utility analysis
Variable name | Variable definition | Source, derivation and application | Expected value and 95 % uncertainty interval |
|---|---|---|---|
Effect of a CCC on increasing receipt of chemotherapy | |||
Proportion surgery only at baseline → surgery and chemotherapy | Proportion shifted from receiving surgery only to surgery plus chemotherapy | Goodwin et al. 2003 [25] and expert estimates | 0.33 (0.09 to 0.65) |
See Additional file 2 | Beta distribution | ||
Hazard ratio (HR) for chemotherapy | Effect of chemotherapy with oxaliplatin on breast cancer mortality | Sargent et al. 2009 [36] | 1: 0.72 (0.61 to 0.85) |
De Gramont et al. 2007 [37] | 2: 0.78 (0.63 to 0.98) | ||
Andre et al. 2004 [38] | Log normal distribution | ||
(Effect of chemotherapy without oxaliplatin on breast cancer mortality considered as scenario analysis) | See Additional file 2 | ||
Product of two HRs: 1: effect of chemo without oxaliplatin compared to no chemo multiplied by 2: effect of chemo with oxaliplatin compared to without oxaliplatin | |||
Effect of a CCC on reducing wait times to treatments | |||
Reduction in days to surgery | Proportionate reduction in days to surgery due to a CCC | Haideri et al. 2011 [10] and expert estimates | 0.20 (0.03 to 0.48) |
See Additional file 2 | Beta distribution | ||
Reduction in EMR per day decrease in time from diagnosis to surgery | Reduction in cancer excess mortality rate (EMR) per day decrease in time from diagnosis to surgery (i.e. the effect of getting surgery faster on colon cancer mortality) | No direct evidence. Estimated using protocol, [39] Whyte et al. 2011, [40] Tappenden et al. 2007 [41] | 0.9972 ratio decrease in EMR per day quicker to surgery (0.9955 to 0.9987) |
Log normal distribution | |||
See Additional file 2 | |||
Reduction in days to chemotherapy | Proportionate reduction in average days from surgery to chemotherapy due to a CCC | Expert estimates | 0.20 (0.03 to 0.48) |
See Additional file 2 | Beta distribution | ||
Reduction in EMR per day decrease in time from surgery to chemotherapy | Reduction in cancer excess mortality rate (EMR) per day decrease in time from surgery to chemotherapy (i.e., the effect of getting chemotherapy faster on colon cancer mortality) | Biagi et al. 2011 [42] | 0.9953 ratio decrease in EMR per day quicker to chemotherapy (0.9983 to 0.9969) |
See Additional file 2 | |||
Log normal distribution | |||
Effect of a CCC on reducing colon cancer morbidity | |||
↓DW due to CCC | Reduction in disability weight (DW) during diagnosis and treatment phase due to a CCC reducing patient anxiety | Ferrante et al. [8] | 0.67 (0.45 to 1.0) |
See Additional file 2 | Log normal distribution | ||