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Table 1 Selected effect size parameters used in the model (greater detail and full list provided in Additional file 2)

From: Cancer care coordinators in stage III colon cancer: a cost-utility analysis

Variable name Variable definition Source, derivation and application Expected value and 95 % uncertainty interval
Effect of a CCC on increasing receipt of chemotherapy
Proportion surgery only at baseline → surgery and chemotherapy Proportion shifted from receiving surgery only to surgery plus chemotherapy Goodwin et al. 2003 [25] and expert estimates 0.33 (0.09 to 0.65)
See Additional file 2 Beta distribution
Hazard ratio (HR) for chemotherapy Effect of chemotherapy with oxaliplatin on breast cancer mortality Sargent et al. 2009 [36] 1: 0.72 (0.61 to 0.85)
De Gramont et al. 2007 [37] 2: 0.78 (0.63 to 0.98)
Andre et al. 2004 [38] Log normal distribution
(Effect of chemotherapy without oxaliplatin on breast cancer mortality considered as scenario analysis) See Additional file 2
Product of two HRs: 1: effect of chemo without oxaliplatin compared to no chemo multiplied by 2: effect of chemo with oxaliplatin compared to without oxaliplatin
Effect of a CCC on reducing wait times to treatments
Reduction in days to surgery Proportionate reduction in days to surgery due to a CCC Haideri et al. 2011 [10] and expert estimates 0.20 (0.03 to 0.48)
See Additional file 2 Beta distribution
Reduction in EMR per day decrease in time from diagnosis to surgery Reduction in cancer excess mortality rate (EMR) per day decrease in time from diagnosis to surgery (i.e. the effect of getting surgery faster on colon cancer mortality) No direct evidence. Estimated using protocol, [39] Whyte et al. 2011, [40] Tappenden et al. 2007 [41] 0.9972 ratio decrease in EMR per day quicker to surgery (0.9955 to 0.9987)
Log normal distribution
See Additional file 2
Reduction in days to chemotherapy Proportionate reduction in average days from surgery to chemotherapy due to a CCC Expert estimates 0.20 (0.03 to 0.48)
See Additional file 2 Beta distribution
Reduction in EMR per day decrease in time from surgery to chemotherapy Reduction in cancer excess mortality rate (EMR) per day decrease in time from surgery to chemotherapy (i.e., the effect of getting chemotherapy faster on colon cancer mortality) Biagi et al. 2011 [42] 0.9953 ratio decrease in EMR per day quicker to chemotherapy (0.9983 to 0.9969)
See Additional file 2
Log normal distribution
Effect of a CCC on reducing colon cancer morbidity
↓DW due to CCC Reduction in disability weight (DW) during diagnosis and treatment phase due to a CCC reducing patient anxiety Ferrante et al. [8] 0.67 (0.45 to 1.0)
See Additional file 2 Log normal distribution