Skip to main content

Table 9 Morphine equivalents utilization in pre- and post-index 6-month periods and difference-in-difference comparison between pregabalin and duloxetine

From: A retrospective, matched cohort study of potential drug-drug interaction prevalence and opioid utilization in a diabetic peripheral neuropathy population initiated on pregabalin or duloxetine

 

Morphine equivalents milligrams/30 days

 

Mean

Standard deviation

Pregabalin

  

Pre-index

525.7

1,682.0

Post-index

585.9

1,539.8

Difference

60.2

899.2

Duloxetine

  

Pre-index

442.6

1,208.0

Post-index

619.5

1,652.7

Difference

176.9

936.5

Difference-in-difference comparison*

60.2 vs. 176.9

 

Statistical difference*

t = −1.90, p = 0.058

  1. *Difference in Difference t-statistic derived from a generalized linear mixed model with an identity link and a Gaussian distribution adjusting for baseline demographics, Deyo-Charlson comorbidity index, and pre- and post-index non-opioid pain medication utilization.