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Table 6 6-month post-index all-cause healthcare costs and component costs stratified by drug-drug interaction status

From: A retrospective, matched cohort study of potential drug-drug interaction prevalence and opioid utilization in a diabetic peripheral neuropathy population initiated on pregabalin or duloxetine

 

Pregabalin

Duloxetine

No DDI present

DDI present

Pvalue*

No DDI present

DDI present

Pvalue*

 

n = 433

n = 13

 

n = 193

n = 253

 

All-Cause Total Healthcare Costs, Mean (SD)

11,085 (16,820)

8,470 (13,491)

0.2156

9,830 (14,351)

13,908 (20,254)

0.001

All-Cause Total Medical Costs, Mean (SD)

8,339 (16,20)

6,115 (13,461)

0.1835

7,550 (14,081)

10,311 (16,609)

0.0278

Outpatient-Related (non-physical therapy), Mean (SD)

2,819 (5,639)

1,944 (2,366)

0.7170

2,711 (4,392)

2,517 (3,999)

0.8396

Physical Therapy-Related, Mean (SD)

93 (385)

17.7 (64.0)

0.5499

98 (363)

103 (516)

0.2824

Inpatient-Related, Mean (SD)

4,082 (12,371)

3,722.5 (13,421.7)

0.1458

3,782 (12,713)

5,873 (13,965)

0.0201

ER-Related, Mean (SD)

248 (700)

217.6 (429.6)

0.9152

224 (675)

386 (900)

0.0061

All-Cause Total Pharmacy Costs, Mean (SD)

2,746 (3,213)

2,355.9 (2,686.5)

0.3120

2,280 (2,396)

3,597 (11,125)

<0.0001

  1. Costs in US Dallars ($).
  2. *All P values for categorical variables calculated using chi-square tests. All P values for continuous variables calculated using Wilcoxon rank-sum tests.
  3. DDI, Drug-Drug Interaction; SD, Standard Deviation.