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Table 6 6-month post-index all-cause healthcare costs and component costs stratified by drug-drug interaction status

From: A retrospective, matched cohort study of potential drug-drug interaction prevalence and opioid utilization in a diabetic peripheral neuropathy population initiated on pregabalin or duloxetine

  Pregabalin Duloxetine
No DDI present DDI present Pvalue* No DDI present DDI present Pvalue*
  n = 433 n = 13   n = 193 n = 253  
All-Cause Total Healthcare Costs, Mean (SD) 11,085 (16,820) 8,470 (13,491) 0.2156 9,830 (14,351) 13,908 (20,254) 0.001
All-Cause Total Medical Costs, Mean (SD) 8,339 (16,20) 6,115 (13,461) 0.1835 7,550 (14,081) 10,311 (16,609) 0.0278
Outpatient-Related (non-physical therapy), Mean (SD) 2,819 (5,639) 1,944 (2,366) 0.7170 2,711 (4,392) 2,517 (3,999) 0.8396
Physical Therapy-Related, Mean (SD) 93 (385) 17.7 (64.0) 0.5499 98 (363) 103 (516) 0.2824
Inpatient-Related, Mean (SD) 4,082 (12,371) 3,722.5 (13,421.7) 0.1458 3,782 (12,713) 5,873 (13,965) 0.0201
ER-Related, Mean (SD) 248 (700) 217.6 (429.6) 0.9152 224 (675) 386 (900) 0.0061
All-Cause Total Pharmacy Costs, Mean (SD) 2,746 (3,213) 2,355.9 (2,686.5) 0.3120 2,280 (2,396) 3,597 (11,125) <0.0001
  1. Costs in US Dallars ($).
  2. *All P values for categorical variables calculated using chi-square tests. All P values for continuous variables calculated using Wilcoxon rank-sum tests.
  3. DDI, Drug-Drug Interaction; SD, Standard Deviation.