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Table 4 Observed pregabalin and duloxetine drug-drug interactions by severity and interacting drug

From: A retrospective, matched cohort study of potential drug-drug interaction prevalence and opioid utilization in a diabetic peripheral neuropathy population initiated on pregabalin or duloxetine

Severity* Interacting drug Number of interactions
Pregabalin   
Major naproxen 17
  Total Major for pregabalin 17
  Grand total for pregabalin 17
Duloxetine   
Contraindicated metoclopramide 11
  Total Contraindicated for duloxetine 11
Major tramadol 35
Major trazodone 31
Major cyclobenzaprine 31
Major meloxicam 29
Major citalopram 25
Major clopidogrel 91
Major methadone 21
Major fluoxetine 25
Major ibuprofen 22
Major escitalopram 11
Major sertraline 32
Major diclofenac 18
Major paroxetine 17
Major celecoxib 9
Major naproxen 9
Major venlafaxine 12
Major nabumetone 4
Major etodolac 3
Major piroxicam 3
Major lithium 4
Major indomethacin 3
Major cilostazol 10
Major sulindac 6
Major propafenone 2
  Total Major for duloxetine 453
Moderate amitriptyline 40
Moderate warfarin 59
Moderate promethazine 15
Moderate ciprofloxacin 14
Moderate tamsulosin 25
Moderate doxepin 8
Moderate nortriptyline 6
Moderate prochlorperazine 3
Moderate enoxaparin 9
Moderate imipramine 1
Moderate dabigatran 1
Moderate butalbital 4
  Total Moderate for duloxetine 185
  Grand total for duloxetine 649
  1. *Severity category according to Micromedex 2.0 (Truven Health Analytics Inc., Greenwood Village, CO), as of May 31, 2013.