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Table 3 Pre-index comorbid conditions

From: A retrospective, matched cohort study of potential drug-drug interaction prevalence and opioid utilization in a diabetic peripheral neuropathy population initiated on pregabalin or duloxetine

  Pregabalin Duloxetine  
  N = 446 N = 446  
  n % n % P value*
Abdominal pain/cramping 106 23.8 107 24.0 0.9374
Anxiety disorder 57 12.8 57 12.8 1
Arthritis 186 41.7 198 44.4 0.4171
Back pain with neuropathic involvement 123 27.6 126 28.3 0.8228
Causalgia and other painful neuropathies 109 24.4 112 25.1 0.8160
Depression 77 17.3 71 15.9 0.5892
Diabetes 388 87.0 397 89.0 0.3537
Epilepsy 9 2.0 10 2.2 0.8166
Fatigue 133 29.8 136 30.5 0.8268
Irritable bowel syndrome 6 1.3 6 1.3 1
Migraine headache 9 2.0 10 2.2 0.8166
Muscle weakness 50 11.2 49 11.0 0.9151
Neck pain with neuropathic involvement 36 8.1 42 9.4 0.4770
Other back pain 165 37.0 168 37.7 0.8355
Other mental disorders 1 0.2 1 0.2 **
Other musculoskeletal pain 333 74.7 338 75.8 0.6982
Other neck pain (spinal) 57 12.8 63 14.1 0.5560
Sleep disorders 111 24.9 114 25.6 0.8171
Substance abuse or dependence 57 12.8 59 13.2 0.8422
Tension headache 5 1.1 4 0.9 **
Thinking/memory loss 12 2.7 8 1.8 0.3657
Trigeminal nerve disorders 2 0.4 0 0.0 **
  Mean SD Mean SD  
Deyo-Charlson Comorbidity Index score 2.6 2.2 2.7 2.2 0.3058
  1. *All P values for categorical variables calculated using chi-square tests. All P values for continuous variables calculated using Wilcoxon rank-sum tests.
  2. **Expected Counts <5. Chi-square test may not be appropriate.
  3. SD, Standard Deviation.