Skip to main content

Table 3 Pre-index comorbid conditions

From: A retrospective, matched cohort study of potential drug-drug interaction prevalence and opioid utilization in a diabetic peripheral neuropathy population initiated on pregabalin or duloxetine

 

Pregabalin

Duloxetine

 
 

N = 446

N = 446

 
 

n

%

n

%

P value*

Abdominal pain/cramping

106

23.8

107

24.0

0.9374

Anxiety disorder

57

12.8

57

12.8

1

Arthritis

186

41.7

198

44.4

0.4171

Back pain with neuropathic involvement

123

27.6

126

28.3

0.8228

Causalgia and other painful neuropathies

109

24.4

112

25.1

0.8160

Depression

77

17.3

71

15.9

0.5892

Diabetes

388

87.0

397

89.0

0.3537

Epilepsy

9

2.0

10

2.2

0.8166

Fatigue

133

29.8

136

30.5

0.8268

Irritable bowel syndrome

6

1.3

6

1.3

1

Migraine headache

9

2.0

10

2.2

0.8166

Muscle weakness

50

11.2

49

11.0

0.9151

Neck pain with neuropathic involvement

36

8.1

42

9.4

0.4770

Other back pain

165

37.0

168

37.7

0.8355

Other mental disorders

1

0.2

1

0.2

**

Other musculoskeletal pain

333

74.7

338

75.8

0.6982

Other neck pain (spinal)

57

12.8

63

14.1

0.5560

Sleep disorders

111

24.9

114

25.6

0.8171

Substance abuse or dependence

57

12.8

59

13.2

0.8422

Tension headache

5

1.1

4

0.9

**

Thinking/memory loss

12

2.7

8

1.8

0.3657

Trigeminal nerve disorders

2

0.4

0

0.0

**

 

Mean

SD

Mean

SD

 

Deyo-Charlson Comorbidity Index score

2.6

2.2

2.7

2.2

0.3058

  1. *All P values for categorical variables calculated using chi-square tests. All P values for continuous variables calculated using Wilcoxon rank-sum tests.
  2. **Expected Counts <5. Chi-square test may not be appropriate.
  3. SD, Standard Deviation.