Variable | Before matching | After matching | ||||
---|---|---|---|---|---|---|
Atypical cohort N = 648 | Typical cohortN = 483 | p-value | Atypical cohort N = 400 | Typical cohort N = 400 | p-value | |
Pharmacy resource utilization | Â | Â | Â | Â | Â | Â |
Use of antipsychotics [mean(SD)] | Â | Â | Â | Â | Â | Â |
Days on of all antipsychotics | 139.1 (109.0) | 143.7 (109.2) | 0.483 | 143.2 (110.7) | 143.9 (108.0) | 0.938 |
Time to all-cause discontinuation | 111.0 (117.8) | 110.2 (114.0) | 0.910 | 113.2 (117.0) | 109.0 (111.8) | 0.606 |
Use of concomitant medication [n(%)] | Â | Â | Â | Â | Â | Â |
Any use of anxiolytics | 476 (73.5%) | 412 (85.3%) | <0.001 | 275 (68.8%) | 342 (85.5%) | <0.001 |
Any use of anticholinergics | 216 (33.3%) | 316 (65.4%) | <0.001 | 143 (35.8%) | 265 (66.3%) | <0.001 |
Any use of antidepressants | 147 (22.7%) | 78 (16.2%) | 0.006 | 80 (20.0%) | 57 (14.3%) | 0.028 |
Any use of sedative-hypnotics | 256 (39.5%) | 122 (25.3%) | <0.001 | 163 (40.8%) | 100 (25.0%) | <0.001 |
Any use of mood stabilizers | 78 (12.0%) | 52 (10.8%) | 0.507 | 47 (11.8%) | 42 (10.5%) | 0.569 |
Medical resource utilization # | Â | Â | Â | Â | Â | Â |
Any psychiatric hospitalization [n(%)] | 297 (45.8%) | 274 (56.7%) | <0.001 | 192 (48.0%) | 231 (57.8%) | 0.002 |
The number of psychiatric hospitalizations [mean(SD)] | 1.65 (0.76) | 1.72 (0.81) | 0.291 | 1.65 (0.76) | 1.71 (0.83) | 0.487 |
Length of stay per hospitalization [mean(SD)] | 85.6 (84.7) | 94.8 (84.2) | 0.094 | 88.3 (86.9) | 92.9 (82.9) | 0.473 |
Any psychiatric outpatient visit [n(%)] | 519 (80.1%) | 318 (65.8%) | <0.001 | 310 (77.5%) | 261 (65.3%) | <0.001 |
The number of psychiatric outpatient visits [mean(SD)] | 7.95 (7.26) | 6.96 (6.25) | 0.044 | 7.71 (6.89) | 6.52 (5.70) | 0.027 |
Mental comorbidities | Â | Â | Â | Â | Â | Â |
Mean number of mental comorbidities [mean(SD)] | 0.72 (0.92) | 0.54 (0.84) | <0.001 | 0.64 (0.87) | 0.49 (0.80) | 0.012 |
Specific mental comorbidities ## [n(%)] | Â | Â | Â | Â | Â | Â |
Sleep disorder | 131 (20.2%) | 84 (17.4%) | 0.231 | 70 (17.5%) | 63 (15.8%) | 0.514 |
Unspecified mental disorder | 112 (17.3%) | 75 (15.5%) | 0.432 | 63 (15.8%) | 59 (14.8%) | 0.700 |
Depression | 110 (17.0%) | 52 (10.8%) | 0.003 | 57 (14.3%) | 39 (9.8%) | 0.052 |
Anxiety disorder | 77 (11.9%) | 37 (7.7%) | 0.020 | 42 (10.5%) | 27 (6.8%) | 0.063 |
Other psychotic disorder | 35 (5.4%) | 13 (2.7%) | 0.025 | 23 (5.8%) | 7 (1.8%) | 0.004 |