Prescribing efficiency of proton pump inhibitors in China: influence and future directions

Table 2 Procured expenditure/DDD (CNY) for the different PPIs (generic and originator) in the Chongqing hospital from 2004 to 2013

PPIs	Dosage form	2004	2005	2006	2007	2008	2009	2010	2011	2012	2013	% change overtime
Omeprazole Generic	Oral	4.15	4.11	3.42	3.27	3.27	3.03	1.85				−55%
Omeprazole Generic	Injection	38.89	34.29	27.16	27.87	27.25	28.09	29.75	29.41	22.91	14.50	−63%
Omeprazole Originator	Oral	14.19	13.87	12.16	12.11	11.86	11.85	11.70	11.58	11.85	11.83	−17%
Omeprazole Originator	Injection	73.21	70.61	65.30	64.65	62.18	62.18	61.28	60.77	56.42	45.32	−38%
Lansoprazole Generic	Oral		9.92	8.33	7.69	7.79	8.10	8.21	6.88	5.74	5.17
Lansoprazole Generic	Injection							110.00	104.11	96.30	93.04
Pantoprazole Generic	Oral	9.86	9.68	8.91	8.44	8.64	8.81	8.83	7.54	6.10	5.22	−47%
Pantoprazole Generic	Injection	92.15	76.74	63.24	58.68	55.31	54.05	53.72	34.13	27.51	21.68	−76%
Pantoprazole Originator	Injection									109.67	108.69
Rabeprazole Generic	Oral	11.99	12.74	15.28	11.50	10.29	10.23	10.11	9.32	8.25	7.78	−35%
Rabeprazole Originator	Oral	33.94	33.15	30.59	31.50	30.37	30.37					−100%
Esomeprazole Originator	Oral	14.08	15.20	13.23	13.72	13.73	12.88	13.20	13.60	12.80	12.64	−10%
Esomeprazole Originator	Injection					93.00	93.00	93.00	93.00	91.65	90.65
Ilaprazole Originator	Oral							32.83	32.34	32.22	32.22
Total oral		12.35	11.91	11.60	10.43	9.84	9.74	9.98	9.24	8.12	8.16	−34%
Total injectable		68.81	64.56	50.97	49.18	41.22	40.84	42.54	47.39	53.07	55.40	−19%
Differences between injectable and oral (fold)		5.6	5.4	4.4	4.7	4.2	4.2	4.3	5.1	6.5	6.8

NB - % change over time typically refers to 2013 vs. 2004. However, this can vary depending when the different formulations were first procured. Blank cells mean no PPI available. Fold = times, e.g. total injectable PPIs in 2004 were 5.6 times more expensive per item than the equivalent oral preparations (DDD based).

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