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Table 5 Results from subgroup analyses

From: Economic evaluation of ivabradine in the treatment of chronic heart failure in Greece

Subgroup

Standard care

Ivabradine + Standard care

Incremental costs & outcomes

Total costs (in €)

Total QALYs

Total costs (in €)

Total QALYs

Costs (in €)

LYs

QALYs

Cost/LY (in €)

Cost/QALY (in €)

All patients (HR ≥ 75 b.p.m.)

5,873

3.99

8,665

4.27

2,792

0.25

0.28

11,002

9,986

Age < 75 years

6,033

4.14

8,932

4.43

2,899

0.27

0.29

10,897

9,909

Age ≥ 75 years

4,350

2.54

6,123

2.69

1,772

0.14

0.16

12,944

11,355

NYHA II

6,358

4.55

9,498

4.84

3,140

0.24

0.28

12,935

11,112

NYHA III

5,528

3.55

8,059

3.83

2,531

0.27

0.28

9,542

9,044

NYHA IV

3,383

1.79

4,726

2.00

1,343

0.22

0.21

6,018

6,445

HF duration <0.6 years

6,683

5.02

10,063

5.35

3,379

0.28

0.33

12,085

10,287

HF duration ≥0.6 < 2 years

5,881

4.10

8,752

4.39

2,871

0.26

0.29

10,919

9,883

HF duration ≥2 < 4.8 years

5,489

3.66

8,138

3.92

2,648

0.24

0.26

10,916

10,168

HF duration ≥4.8 years

5,466

3.20

7,755

3.44

2,290

0.23

0.24

9,931

9,527

No beta blocker

5,144

3.08

7,384

3.39

2,240

0.31

0.31

7,239

7,267

Beta blocker < half target dose

5,481

3.60

7,992

3.87

2,511

0.25

0.27

9,942

9,250

Beta blocker = > half target dose < target dose

6,338

4.45

9,438

4.73

3,100

0.24

0.28

12,794

11,115

Beta blocker = > target dose

6,440

4.64

9,684

4.92

3,244

0.24

0.28

13,602

11,619

LVEF < 26%

5,407

3.31

7,709

3.60

2,302

0.28

0.29

8,356

8,072

LVEF ≥26% < 30%

5,483

3.66

8,052

3.94

2,569

0.25

0.27

10,163

9,440

LVEF ≥30 < 33%

5,993

4.19

8,947

4.47

2,955

0.26

0.28

11,558

10,400

LVEF ≥ 33%

6,443

4.64

9,688

4.92

3,245

0.23

0.27

13,977

11,807

Non-diabetic

5,746

4.04

8,577

4.32

2,831

0.25

0.28

11,210

10,112

Diabetic

6,150

3.86

8,859

4.14

2,709

0.26

0.28

10,556

9,710

No prior CAD

5,839

4.20

8,719

4.52

2,880

0.29

0.32

9,907

9,051

Prior CAD

5,887

3.90

8,643

4.16

2,756

0.24

0.26

11,549

10,448

  1. HR: Heart rate; CAD: coronary artery disease; HF: Heart Failure; LY: life Years; QALY: Quality-adjusted-life year; NYHA: New York Heart Association; LVEF: Left Ventricular Ejection Fraction.