Comparing methods for identifying patients with heart failure using electronic data sources

Table 2 Performance of various definitions for heart failure in derivation set (n = 300)*

#	Heart failure criteria based on claims and laboratory data	Sensitivity	Specificity	AUC
1	≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR BNP ≥ 200 pg/ml	76.29	74.53	0.754
2	≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure	68.56	81.13	0.748
3	≥2 heart failure encounters OR BNP ≥ 200 pg/ml	69.59	79.25	0.744
4	≥2 heart failure encounters OR *any hospital discharge diagnosis of heart failure OR*BNP ≥ 500 pg/ml	69.59	78.3	0.739
5	≥2 heart failure encounters OR primary hospital discharge diagnosis of heart failure	60.31	85.85	0.729
6	≥2 heart failure encounters OR BNP ≥ 100 pg/ml	76.29	68.87	0.726
7	≥2 heart failure encounters	58.76	85.85	0.723
8	≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR any hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 200 pg/ml	59.28	81.13	0.702
9	≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR primary hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 500 pg/ml	38.66	90.57	0.646
10	Any hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml	40.72	87.74	0.642
11	Any hospital discharge diagnosis of heart failure	35.05	91.51	0.633
12	BNP ≥ 100 pg/ml	48.97	76.42	0.627
13	BNP ≥ 200 pg/ml	36.08	87.74	0.619
14	Primary hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml	24.23	95.28	0.598
15	BNP ≥ 500 pg/ml	20.1	95.28	0.577
16	Any primary hospital discharge diagnosis of heart failure	14.95	100	0.575

*Calculated sensitivity, specificity, and area under curve for each claim signature is compared to the Framingham definition of heart failure (i.e., meeting either two major criteria or one major and two minor criteria).

ISSN: 1472-6963