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Table 1 Overview of human cell-derived wound care products for the management of chronic leg ulcers investigated by health economic evaluation

From: Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers

Product Description Indications Manufacturer
Apligraf® Bi-layered skin substitute: the epidermal layer is composed of human keratinocytes; the dermal layer is formed by human fibroblasts in a bovine type I collagen matrix ▪ Non-infected partial and full-thickness venous leg ulcers
▪ Full-thickness neuropathic diabetic foot ulcers
Organogenesis, US
Becaplermin (REGRANEX® Gel) Clear colourless to straw-coloured gel, which contains 0.01% of the active substance becaplermin ▪ Deep neuropathic diabetic foot ulcers Systagenix Wound Management, US
Dermagraft® Cryopreserved human fibroblast-derived dermal substitute composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold ▪ Full-thickness diabetic foot ulcers Advanced BioHealing, US