Table 4 Factors preventing clinical trial participation, by specialty and current participation in clinical research*
From: Factors influencing the participation of gastroenterologists and hepatologists in clinical research
Factor | Specialty | Clinical Research Participation | ||
|---|---|---|---|---|
| Â | Gastroenterology (n = 160) | Hepatology (n = 189) | Clinical Researchers (n = 221) | Non-Clinical Researchers (n = 163) |
Increasing complexity of trials | 12 (8.1) | 10 (5.4) | 10 (4.7) | 13 (8.4) |
Excessive trial costs not covered by the trial sponsor | 76 (50.7) | 98 (52.7) | 115 (54.5)†| 73 (46.5) |
Complexity of Institutional Review Board requirements | 20 (13.3) | 10 (5.4) | 18 (8.5) | 15 (9.6) |
Inferior trial medication(s) compared to standard therapy | 65 (43.3) | 86 (46.0) | 115 (54.0)†| 54 (34.6) |
Lack of specialized support staff | 50 (32.9) | 71 (38.0) | 52 (24.4)†| 80 (50.6) |
Concern about sponsor control of trial decision-making, data, publication, etc | 22 (14.8) | 37 (19.9) | 54 (25.6)†| 18 (11.5) |
Too busy with clinical practice commitments | 37 (24.3) | 46 (24.7) | 14 (6.6)†| 74 (46.8) |
Ethical considerations | 41 (27.2) | 45 (24.1) | 70 (32.9)†| 26 (16.6) |
Difficulty in accessing the appropriate patient population | 15 (9.9) | 18 (9.6) | 25 (11.7)†| 13 (8.3) |
Not interested in participating in sponsored clinical research | 14 (9.4)†| 22 (11.9) | 7 (3.3)†| 32 (20.5) |