From: Sleep disturbances in an arctic population: The Tromsø Study
Sleep outcome variables against potential explanatory variables | Pre-specified associations | References |
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Initial screening of all eligible participants in the Tromsø Study: | ||
• Prevalence of sleep disturbances reported in the initial questionnaire (Questionnaire 1) containing a four-item response option, where sleep disturbance is defined as the average occurrence of sleep problems "more than once a week". | 10 to 50% in the adult population. | [2, 76] |
• Sleep disturbances and their possible relationships, including demographic variables, health-related variables, and lifestyle and socioeconomic variables, and biological markers. | Increased risk for impairments in health, decreased quality of life and increased healthcare utilization. | [19, 65, 77-80] |
Further mapping with validated sleep assessment questionnaires among subjects with sleep complaints selected in the initial screening and their control group: | ||
• Sleep outcome variables related to the use (dose and frequency) of specific prescription drugs, derived from the Norwegian Prescription Database (NorPD). | Frequent use of hypnotics and over-the-counter (OTC) medications. | [36, 37] |
• Sleep outcome variables related to socioeconomic variables. | Insomnia related to unemployment and socioeconomic deprivation, more common in women, elderly and individuals living alone. | [81, 82] |
• Sleep outcome variables and excessive daytime sleepiness related to objective medical diagnosis, such as diabetes and coronary disease. | A possible link between short sleep, diabetes mellitus, coronary heart disease and all over mortality. | [21, 25-28] |
• Sleep outcome variables related to the diagnosis of restless legs. | Relation between symptoms of restless legs and insomnia | [15] |
• Sleep outcome variables related to self-reported complaints of musculoskeletal symptoms. | Relation between symptoms of musculoskeletal symptoms and insomnia | [83] |
• Sleep outcome variables related to self-reported psychiatric symptoms | Elevated risk of depression and anxiety disorders in people with persistent insomnia | [58, 77, 84-86] |
• Sleep outcome variables related to self-reported frequency of nightmares. | Possible association between nightmares and being a woman, feeling depressed after a poor night's sleep, and complaining of a long sleep latency. | [87] |
• Sleep outcome variables related to excessive daytime sleepiness and reported actual sleep length. | Daytime sleepiness inversely related to hours of sleep and positively related to the ease of falling asleep at night, especially among young adults. | [88, 89] |
• Sleep outcome variables and excessive daytime sleepiness related to subjective perceptions of pain | Chronic pain populations are more likely to experience chronic insomnia, sleep maintenance problems, and/or nonrestorative sleep. | [17, 35, 90] |
• Sleep outcome variables and excessive daytime sleepiness related to doctor-seeking behaviour. | Although insomnia is related to more consultations with GPs, many individuals hesitate to consult their doctor about insomnia | [72, 82] |