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Table 1 Liver function tests and definitions of abnormal

From: Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluation (ALFIE)

Liver Function test Range Normal (Age & Gender) Moderately abnormal Severely abnormal
Bilirubin (μmol/l) 0–1000 <18 M
<16 F
18 – 42.5 M
16 – 37.5 F
>42.5 M
>37.5 F
Albumin (g/l) 11–60 >35 30–35 <30
Alk Phos (IU/l) 20–2000 120–455 M 16–19 455–1138 >1138
   45 – 195 M 19–26 195–488 >488
   30 – 105 M 26–55 105–263 >263
   45 – 130 M 56–75 130–325 >325
   65 – 150 M 75+ 150–375 >375
   120–420 F 16–19 420–1050 >1050
   25 – 90 F 19–26 90–225 >225
   20 – 80 F 26–55 80–200 >200
   40 – 150 F 56–75 150–375 >375
   50 – 190 F 75+ 190–475 >475
GGT (IU/l) 5–2000 7 – 42 All 16–24 42–105 >105
   9 – 70 M 24–34 70–175 >175
   11– 75 M 34–44 75–188 >188
   11 – 82 M 44–55 82–205 >205
   11 – 70 M 55+ 70–175 >175
   5 – 35 F 24–34 35–88 >88
   5 – 42 F 34–44 42–105 >105
   5 – 65 F 44–55 65–163 >163
   5 – 75 F 55+ 75–188 >188
ALT (IU/l) 12–9999 depending on age and sex 14 – 40 M 16–18 40–100 >100
   15 – 55 M 18–55 55–138 >138
   12 – 35 F 16–18 35–88 >88
   12 – 40 F 18–55 40–100 >100
   13 – 43 All 55–75 43–108 >108
   6 – 30 All 75+ 30–75 >75
AST (IU/l)   3 – 30 M 17–65 30 – 75 >75
   10 – 45 F 16–75 45 – 113 >113
   10 – 30 75+ 30 – 75 >75