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Table 5 Frequency of liver-related diagnostic codes according to the development of hepatotoxicity *

From: Validation of ICD-9-CM/ICD-10 coding algorithms for the identification of patients with acetaminophen overdose and hepatotoxicity using administrative data

Clinical Diagnosis (Codes) Hepatotoxicity (n = 59) No Hepatotoxicity (n = 73) Odds Ratio (95% CI) P-value
Hepatic necrosis (570, K71.1) 42.4% (25) 4.1% (3) 17.16 (4.65–92.85) < 0.0005
Toxic hepatitis (573.3, K71.2, K71.6, K71.9) 48.2% (29) 11.0% (8) 7.85 (3.01–21.98) < 0.0005
Hepatic encephalopathy (572.2, K72.0, K72.9) 15.3% (9) 1.4% (1) 12.96 (1.67–575.6) 0.005
Coagulopathy (286.7, D68.4, D68.9) 6.8% (4) 4.1% (3) 1.70 (0.27–12.02) 0.70
ARDS (582.82, J80) 1.7% (1) 0% -- 0.45
  1. * In patients identified by the acetaminophen overdose coding algorithm including codes 965.4 and T39.1. Codes for jaundice and hepatorenal syndrome were not recorded in any patient.
  2. ARDS, adult respiratory distress syndrome. CI, confidence interval.