Table 3 Operating characteristics of the coding algorithms according to diagnostic coding system (ICD-9-CM vs. ICD-10) *
Outcome/Coding System | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | C-statistic (95% CI) |
|---|---|---|---|---|---|
Acetaminophen overdose | |||||
ICD-9-CM | 91% (83–96%) (81/89) | 81% (61–93%) (21/26) | 94% (87–98%) (81/86) | 72% (53–87%) (21/29) | 0.86 (0.78–0.94) |
ICD-10 | 88% (77–95%) (44/50) | 88% (62–98%) (14/16) | 96% (85–99%) (44/46) | 70% (46–88%) (14/20) | 0.88 (0.78–0.97) |
Hepatotoxicity | |||||
ICD-9-CM | 97% (86–100%) (36/37) | 80% (66–90%) (39/49) | 78% (64–89%) (36/46) | 98% (87–100%) (39/40) | 0.88 (0.82–0.95) |
ICD-10 | 86% (65–97%) (19/22) | 96% (79–100%) (23/24) | 95% (75–100%) (19/20) | 88% (70–98%) (23/26) | 0.91 (0.83–0.99) |
Acute liver failure | |||||
ICD-9-CM | 85% (55–98%) (11/13) | 85% (75–92%) (62/73) | 50% (28–72%) (11/22) | 97% (89–100%) (62/64) | 0.85 (0.74–0.96) |
ICD-10 | 100% (N/A) (9/9) | 86% (71–95%) (32/37) | 64% (35–87%) (9/14) | 100% (NA) (32/32) | 0.93 (0.88–0.99) |