Table 4 Sensitivity analysis estimates of incremental cost-effectiveness ratios (ICER) of providing "IUI+IVF" compared to primary offer of IVF, varied sequentially.
Varied variables | Source of assumption | ICER (£/live birth-producing pregnancy) | |||||
|---|---|---|---|---|---|---|---|
1 cycle of IUI | 2 cycles of IUI | 3 cycles of IUI | 4 cycles of IUI | 5 cycles of IUI | 6 cycles of IUI | ||
S-IUI | |||||||
LBR = 8.7% | Goverde et al 13 | £10,400 | £10,900 | £11,600 | £12,300 | £13,000 | £13,800 |
LBR varying by cycle order* | Local unit's experience and peer-reviewed literature 6–10 | £7,700 | £12,300 | £16,800 | £19,900 | £24,300 | £28,300 |
U-IUI | |||||||
LBR = 4.4% | LBR of U-IUI as half of that of S-IUI11 | £0 | £7,500 | £8,700 | £9,300 | £9,800 | £10,200 |
LBR = 2% | Local experience and expert opinion | ¶ | £91,700 | £42,400 | £35,700 | £33,300 | £32,100 |
LBR varying by cycle order± | LBR of U-IUI as half of that of S-IUI11 | £41,600 | £40,400 | £47,600 | £51,900 | £54,900 | £57,100 |
C-IUI | |||||||
LBR = 6.6% | Reasonable assumption, LBR of C-IUI between the values of LBR of U-IUI and S-IUI | £9,500 | £10,500 | £10,700 | £10,800 | £10,900 | £10,900 |
LBR = 2.5% | Local experience and expert opinion | ¶ | £81,900 | £53,900 | £46,900 | £43,700 | £41,900 |