1. Indication for use | |
---|---|
Criteria | Exception |
May be used: | May be used |
1.1 For empirical treatment (no investigation): symptoms of dysmotility with or without gastro-oesophagus reflux symptoms | 1.1 1) If dysphagia, more than 3 vomiting episodes per week, or gastro-intestinal bleeding not related to another cause 2) If mechanical obstruction or intestinal perforation. |
1.2 For non empirical treatment (with investigation): symptoms of dysmotility with or without gastro-oesophagus reflux symptoms AND absence of moderate to severe oesophagitis at endoscopy (Savary-Miller grade III or IV) | 1.2 1) For moderate to severe oesophagitis if prescribed with a proton pump inhibitor (lansoprazole, omeprazole, pantoprazole) 2) If mechanical obstruction or intestinal perforation. |
1.3 For gastroparesia | 1.3 If mechanical obstruction or intestinal perforation. |
1.4 For chronic pseudo-obstruction | 1.4 If mechanical obstruction or intestinal perforation. |
2. Contra-indicated drugs (combination therapy) | |
Criteria | Exception |
Must not be used: | May be used: |
2.1 With domperidone or metoclopramide | |
2.2 With proton pump inhibitors | 2.2 With proton pump inhibitors when moderate to severe oesophagitis |
2.3 With an Anti-H2 | |
3. Dosage | |
Criterion | Exception |
3.1 Maximum of 80 mg/day; 20 mg/dose, 4 doses/day | 3.1 If > 80 years old or hepatic failure: Maximum of 40 mg/day; 10 mg/dose |
4. Drug interactions | |
Criterion | Exception |
Must not be used: 4.1 Concurrently with erythromycin, clarithromycin, fluconazol, ketoconazol, itraconazol, nefazodone, nicoumalone or warfarin | May be used: 4.1 In presence of nicoumalone or warfarin if international normalized ratio obtained 1 week after addition of cisapride and at cessation if stopped |