Table 10 Example of a modified GRADE evidence profile summary of findings. Table 9 and 10 is what Table 1 and 2 became when including the improvements made based on the pilot study experience
Outcome | SSRI | Tricyclics | Effect | Quality | Importance | |
|---|---|---|---|---|---|---|
Relative (95% CI) | Absolute | |||||
Depression severity | 5044 patients | 4510 patients | WMD 0.034 (-0.007 to 0.075) | No difference | Moderate | Critical |
Transient side effects | 1948/7032 (28%) | 2072/6334 (33%) | RRR 13% (5% to 20%) | 5 per 100 | High | Critical |
Poisoning fatalities*** | 1/100,000 per year of treatment | 58/100,000 per year of treatment | RRR 98% (97% to 99%) | 6 per 10,000 | Moderate | Critical |