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Table 2 Causes for drug shortages reported in national reporting systems

From: Drug shortages in European countries: a trade-off between market attractiveness and cost containment?

Production problems

 

Italy

Production problem (at European level)

France

Problems with production

Impurities found in syringe

Lack of active substance

Contamination particular lots

Germany

Production problem

Technical defect in the production procces

Problems with manufacturing the solvent

Inability to meet the demand due to problem GMP compliance

Belgium

Production problem

Re-engineering of the process and equipment at sterile production site

Availability of raw material

The Netherlands

Production problems

Delay startup new production line

Problems with raw materials

Recall of a batch

Problems with quality

Possible contamination

England

Manufacturing issues

Spain

Problems with sterility based on inspection in France and UK

Economic reason

 

Italy

Commercial problem

Belgium

Stop due to commercial reasons

The Netherlands

Economic reasons

Other

 

Italy

Administrative problem

Natural disaster

Regulatory problem

France

Mistake in labeling

England

Shortage of active pharmaceutical ingredient

Stop supply of alternative

Spain

Marketing authorization cancelled

Belgium

Limited stock because unavailability of alternative product

Problem of stock

The Netherlands

Increased demand

Delayed supply

Logistic problems

Moving production sites

Extensive controll

Delay in delivery of new packages