Table 4 Cumulative incidence of long-term complications for liraglutide, sitagliptin and exenatide BID*
Complication | Liraglutide 1.2 mg | Sitagliptin | Difference | Liraglutide 1.8 mg | Exenatide BID | Difference |
|---|---|---|---|---|---|---|
Eye disease, % | ||||||
Background retinopathy | 17.18 (1.26) | 19.26 (1.29) | −2.08 | 18.64 (1.24) | 20.91 (1.27) | −2.27 |
Proliferative retinopathy | 0.51 (0.22) | 0.67 (0.27) | −0.15 | 0.61 (0.25) | 0.78 (0.27) | −0.17 |
Severe vision loss | 6.78 (0.76) | 7.51 (0.83) | −0.73 | 6.59 (0.78) | 7.46 (0.86) | −0.87 |
Macular edema | 13.59 (1.11) | 15.44 (1.14) | −1.85 | 12.95 (1.04) | 14.88 (1.08) | −1.93 |
Cataract | 10.62 (0.96) | 11.11 (1.02) | −0.49 | 10.27 (1.02) | 10.85 (1.05) | −0.58 |
Renal disease, % | ||||||
Microalbuminuria | 24.22 (1.35) | 27.02 (1.44) | −2.80 | 28.95 (1.43) | 31.87 (1.55) | −2.92 |
Gross proteinuria | 5.07 (0.71) | 6.38 (0.78) | −1.30 | 6 (0.78) | 7.26 (0.81) | −1.26 |
End-stage renal disease | 0.58 (0.23) | 0.83 (0.29) | −0.26 | 0.65 (0.26) | 0.90 (0.3) | −0.26 |
Diabetic foot & neuropathy, % | ||||||
Foot ulcer | 30.91 (1.42) | 32.97 (1.48) | −2.07 | 28.36 (1.35) | 30.21 (1.4) | −1.85 |
Amputation | 10.06 (1.05) | 10.54 (1.01) | −0.48 | 8.63 (0.98) | 9.13 (1.01) | −0.51 |
Neuropathy | 47.51 (1.75) | 52.27 (1.69) | −4.76 | 45.74 (1.61) | 50.13 (1.71) | −4.39 |
Cardiovascular disease, % | ||||||
Congestive heart failure | 13.23 (1.05) | 14.29 (1.08) | −1.06 | 13.54 (1.09) | 14.31 (1.15) | −0.78 |
Peripheral vascular disease | 9.34 (0.90) | 10.82 (1) | −1.49 | 8.69 (0.88) | 10.43 (0.94) | −1.73 |
Angina | 13.01 (1.11) | 13.52 (1.11) | −0.51 | 12.05 (1.02) | 12.87 (1.08) | −0.82 |
Stroke | 8.79 (0.95) | 9.24 (0.91) | −0.46 | 8.69 (0.94) | 9.45 (0.92) | −0.76 |
Myocardial infarction | 17.16 (1.19) | 17.83 (1.22) | −0.68 | 16.31 (1.17) | 17.55 (1.25) | −1.24 |
Hypoglycaemia, % | ||||||
Major hypoglycaemia | 0.11 (0.01) | 0 (0) | 0.11 | 0 (0) | 0.22 (0.02) | −0.22 |
Minor hypoglycaemia | 23.63 (0.48) | 22.88 (0.45) | 0.75 | 31.66 (0.50) | 34.49 (0.46) | −2.84 |