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Table 3 Health state, event, drug acquisition and consumable costs used in the analysis, expressed in 2013 Euros (€)

From: Cost-effectiveness analysis of liraglutide versus sitagliptin or exenatide in patients with inadequately controlled Type 2 diabetes on oral antidiabetic drugs in Greece

Cost description Costs (€) Reference
Management costs   
Annual cost of statins 147.97 Experts opinion & Drug price bulletin [15]
Annual cost of aspirin 14.41 Experts opinion & Drug price bulletin [15]
Annual cost of ACE inhibitors 78.32 Experts opinion & Drug price bulletin [15]
Annual cost of screening for microalbuminuria 8.66 Government Gazette*
Annual cost of screening for gross proteinuria 8.66 Government Gazette*
Annual cost of stopping ACEIs due to side effects 15.00 Experts opinion
Annual cost of eye screening 10.00 Experts opinion & Government Gazette
Annual cost of foot screening program 10.00 Experts opinion & Government Gazette
Annual cost of non-standard ulcer treatment 0.00 This is a patient’s expenditure
Annual cost of anti-depression treatment 154.50 Experts opinion & Drug price bulletin [15]
Annual cost of screening for depression 10.00 Experts opinion & Government Gazette
Direct costs of cardiovascular complications  
Myocardial infarction, 1st year of event 6000 G. Kourlaba et al. [19]
Myocardial infarction, each subsequent year 1964 G. Kourlaba et al. [19]
Angina, 1st year of event 3613 National School of Public Health (data on file)
Angina, each subsequent year 1197 National School of Public Health (data on file)
Congestive heart failure, year of onset 3910 National School of Public Health (data on file)
Congestive heart failure, each subsequent year 1398 National School of Public Health (data on file)
Stroke, 1st year of event 4406 G. Kourlaba et al. [19]
Stroke, each subsequent year 1976 G. Kourlaba et al. [19]
Stroke, death within 30 days 3675 Government Gazette (DRG-code: N30Mα) & G. Kourlaba et al. [19]
Peripheral vascular disease, year of onset 5713 G. Kourlaba et al. [20]
Peripheral vascular disease, each subsequent year 1426 G. Kourlaba et al. [20]
Direct costs of renal complications   
Hemodialysis, first year 40352 D. Kaitelidou et al. & K. Souliotis et al. [17, 18]
Hemodialysis, each subsequent year 40352 Assumed equal with 1st year hemodialysis cost
Peritoneal dialysis, first year 46156 Experts opinion & Government Gazette (DRGs-code: Υ28Α and Y02M)
Peritoneal dialysis, each subsequent year 43656 Experts opinion & Government Gazette (DRG-code: Υ28Α)
Kidney transplant, first year 18489 S. Sidiropoulos [21]
Kidney transplant, each subsequent year 5400 K. Souliotis et al. [17]
Direct costs of acute events   
Major hypoglycaemic event 700 National School of Public Health (data on file)
Minor hypoglycaemic event 250 National School of Public Health (data on file)
Direct costs of eye disease   
Cost of laser treatment 731 Government Gazette† (DRG-code: O03A)
Cost of cataract operation 933 Government Gazette† (DRG-code: O15A)
Cost following cataract operation 59 Experts opinion & Drug price bulletin [15]
Cost of blindness in year of onset 11280 Experts opinion & K. Athanasakis et al. [16]
Cost of blindness in subsequent years 6200 Experts opinion & K. Athanasakis et al. [16]
Direct costs of neuropathy, foot ulcer and amputation
Neuropathy, year of onset 1120 Experts opinion, Drug price bulletin [15] & Government Gazette¶‡
Neuropathy, each subsequent year 1120 Experts opinion, Drug price bulletin [15] & Government Gazette¶‡
Amputation, year of event 6629 Government Gazette† (DRG-code: K11M)
Amputation, prosthesis 1150 Government Gazette
Gangrene treatment 5282 Experts opinion, Drug price bulletin [15] & Government Gazette (DRGs-code: K11M & K13M)
Cost of infected ulcer treatment 2835 Experts opinion, Drug price bulletin [15] & Government Gazette¶† (DRG-code: Δ20Μ)
Cost of uninfected ulcer treatment 387 Experts opinion, Drug price bulletin [15] & Government Gazette
Cost after healed ulcer 120 Experts opinion & Government Gazette
Cost of healed ulcer (history of amputation) 1471 Government Gazette† (DRG-code: Δ20Χ)
Costs of interventions   Drug price bulletin [15]
Liraglutide (1.2 mg) 3.44 per day  
Liraglutide (1.8 mg) 5.16 per day  
Sitagliptin 1.30 per day  
Exenatide BID 2.84 per day  
Metformin 0.11 per day  
Sulphonylurea (Glimepiride) 0.14 per day  
Basal insulin (Glargine) 1.38 per day  
Consumable costs   Government Gazette#
Needles for injectable drugs 0.17 per needle  
SMBG test strips 0.43 per strip  
SMBG lancets 0.09 per lancet  
  1. *Reimbursement for screening tests (Ministerial Decree, Α4 /2878/4-6-1992).
  2. Reimbursement for a doctor’s office visit (Presidential Decree, FEK 262A’/16-12-2011).
  3. Reimbursement for diagnosis-related groups (Common Ministerial Decree, FEK 946B’/27-3-2012).
  4. EOPYY Health Provision Policy Regulation (Common Ministerial Decree, FEK 3054B’/18-11-2012).
  5. #Reimbursement for consumables (Common Ministerial Decree, FEK 1561B’/21-06-2013).
  6. ACE = Angiotensin-converting enzyme; SMBG = Self-monitoring blood glucose, DRG = Diagnosis-related group.