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Table 4 Adverse Events (AE) from non-adherence and under-treatment and Adverse Drug Events (ADE) by study group

From: Effect of a care transition intervention by pharmacists: an RCT

  Enhanced Minimal Control P-values*
Initial Hospitalization n = 311 n = 312 n = 313  
Number of possible adverse events 40 43 40  
Number of AEs due to medication non-adherence† 9 9 6  
Number of AEs due to medication under-treatment† 1 3 3  
Number of ADEs† 15 16 15  
Percent of participants with any AE or ADE† 18 (5.8%) 19 (6.1%) 22 (7.0%) E + M vs. C: 0.52
During Hospitalization     
Number of possible adverse events 55 52 57  
Number of AEs due to medication non-adherence † 1 2 0  
Number of preventable medication non-adherence AEs‡ 1 2 0  
Number of AEs due to medication under-treatment † 2 0 1  
Number of preventable medication under-treatment AEs‡ 2 0 1  
Number of ADEs† 18 27 16  
Number of preventable ADEs‡ 0 3 1  
Percent of participants with any AE or ADE† 19 (6.1%) 19 (6.1%) 14 (4.5%) E + M vs. C: 0.31
Post-Discharge n = 306 n = 309 n = 311  
Number of possible adverse events 183 180 174  
Number of AEs due to medication non-adherence† 15 8 10  
Number of preventable medication non-adherence AEs‡ 15 7 9  
Number of AEs due to medication under-treatment† 10 13 6  
Number of preventable medication under-treatment AEs‡ 6 11 5  
Number of ADEs† 47 49 60  
Number of preventable ADEs‡ 8 7 9  
Percent of participants with any AE or ADE† 48 (15.7%) 50 (16.2%) 53 (17.0%) E vs. C: 0.72
     M vs. C: 0.95
  1. *E = enhanced, M = minimal and C = control groups.
  2. †Medication non-adherence and under-treatment were labeled adverse events (AEs) and counted only if the rating was “Virtually certain” or “Strong level of confidence”. ADEs were counted only if the Naranjo score was 5 or greater.
  3. ‡AEs and ADEs were considered preventable if the rating was “Definitely preventable” or “Probably preventable”.