Table 4 Cost of primary medication, medication for medical castration, bone-targeted therapy per patient, by line of treatment of mCRPC
From: Drug costs in the management of metastatic castration-resistant prostate cancer in Canada
Treatment sequence | Primary medication | Medication for medical castration* | Bone-targeted therapy** | Total | ||||
|---|---|---|---|---|---|---|---|---|
Current model | Mean cost (95%CI) | Median cost (IQR) | Mean cost (95%CI) | Median cost (IQR) | Mean cost (95%CI) | Median cost (IQR) | Mean cost (95%CI) | Median cost (IQR) |
AA | $500 | $410 | $3,002 | $2,467 | $4,485 | $3,686 | $7,988 | $6,563 |
($495-$505) | ($293-$705) | ($2,972-$3,032) | ($1,762-$4,229) | ($4,440-$4,530) | ($2,633-$6,318) | ($7,907-$8,067) | ($4,688-$11,251) | |
AAwd | $0 | $0 | $1,526 | $1,409 | $2,280 | $2,106 | $3,806 | $3,515 |
| Â | Â | ($1,513-$1,538) | ($1,057-$2,114) | ($2,261-$2,299) | ($1,580-$3,159) | ($3,775-$3,837) | ($2,636-$5,273) | |
Docetaxel | $6,172 | $6,124 | $2,487 | $2,467 | $3,715 | $3,686 | $12,374 | $12,277 |
($6,126-$6,219) | ($6,124-$6,999) | ($2,467-$2,506) | ($2,467-$2,819) | ($3,687-$3,743) | ($3,686-$4,212) | ($12,280-$13,468) | ($12,277-$14,031) | |
Abiraterone | $34,624 | $31,040 | $3,538 | $3,172 | $5,285 | $4,739 | $43,448 | $38,950 |
($34,032-$35,217) | ($13,796-$58,631) | ($3,477-$3,599) | ($1,409-$5,991) | ($5,195-$5,376) | ($2,106-$8,950) | ($42,706-$44,192) | ($17,311-$73,573) | |
OtherTx | $0 | $0 | $5,130 | $5,287 | $7,664 | $7,898 | $12,794 | $13,184 |
| Â | Â | ($5,021-$5,239) | ($2,115-$8,459) | ($7,501-$7,862) | ($3,159-$12,636) | ($12,523-$13,065) | ($5,274-$21,095) | |
Alternate model | Â | Â | Â | Â | Â | Â | Â | Â |
AA | $504 | $470 | $3,025 | $2,819 | $4,519 | $4,212 | $8,049 | $7,501 |
($498-$509) | ($294-$704) | ($2,995-$3,055) | ($1,762-$4,229) | ($4,474-$4,564) | ($2,632-$6,318) | ($7,968-$8,128) | ($4,688-$11,251) | |
AAwd | $0 | $0 | $1,541 | $1,410 | $2,303 | $2,106 | $3,844 | $3,515 |
| Â | Â | ($1,529-$1,554) | ($1,057-$2,115) | ($2,283-$2,321) | ($1,580-$3,159) | ($3,812-$3,874) | ($2,637-$5,273) | |
Abiraterone | $69,512 | $65,531 | $7,103 | $6,697 | $10,611 | $10,003 | $87,227 | $82,231 |
($68,593-$70,431) | ($31,041-$120,715) | ($7,009-$7,197) | ($3,172-$12,335) | ($10,470-$10,751) | ($4,738-$18,428) | ($86,073-$88,381) | ($38,952-$151,478) | |
Docetaxel | $6,143 | $6,118 | $2,477 | $2,467 | $3,701 | $3,686 | $12,321 | $12,271 |
($6,083-$6,203) | ($6,118-$6,992) | ($2,453-$2,501) | ($2,467-$2,819) | ($3,665-$3,737) | ($3,686-$4,212) | ($12,201-$12,441) | ($12,271-$14,024) | |
Cabazitaxel | $49,131 | $43,125 | $2,007 | $1,762 | $2,999 | $2,632 | $54,138 | $47,519 |
($48,366-$49,895) | ($34,500-$60,375) | ($1,977-$2,038) | ($1,409-$2,467) | ($2,952-$3,046) | ($2,106-$3,685) | ($53,295-$54,980) | ($38,016-$66,528) | |
OtherTx | $0 | $0 | $5,300 | $5,639 | $7,918 | $8,424 | $13,217 | $14,063 |
| Â | Â | ($5,186-$5,414) | ($2,467-$8,459) | ($7,747-$8,087) | ($3,685-12,636) | ($12,933-$13,501) | ($6,153-$21,095) | |