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Table 4 Cost of primary medication, medication for medical castration, bone-targeted therapy per patient, by line of treatment of mCRPC

From: Drug costs in the management of metastatic castration-resistant prostate cancer in Canada

Treatment sequence Primary medication Medication for medical castration* Bone-targeted therapy** Total
Current model Mean cost (95%CI) Median cost (IQR) Mean cost (95%CI) Median cost (IQR) Mean cost (95%CI) Median cost (IQR) Mean cost (95%CI) Median cost (IQR)
AA $500 $410 $3,002 $2,467 $4,485 $3,686 $7,988 $6,563
($495-$505) ($293-$705) ($2,972-$3,032) ($1,762-$4,229) ($4,440-$4,530) ($2,633-$6,318) ($7,907-$8,067) ($4,688-$11,251)
AAwd $0 $0 $1,526 $1,409 $2,280 $2,106 $3,806 $3,515
   ($1,513-$1,538) ($1,057-$2,114) ($2,261-$2,299) ($1,580-$3,159) ($3,775-$3,837) ($2,636-$5,273)
Docetaxel $6,172 $6,124 $2,487 $2,467 $3,715 $3,686 $12,374 $12,277
($6,126-$6,219) ($6,124-$6,999) ($2,467-$2,506) ($2,467-$2,819) ($3,687-$3,743) ($3,686-$4,212) ($12,280-$13,468) ($12,277-$14,031)
Abiraterone $34,624 $31,040 $3,538 $3,172 $5,285 $4,739 $43,448 $38,950
($34,032-$35,217) ($13,796-$58,631) ($3,477-$3,599) ($1,409-$5,991) ($5,195-$5,376) ($2,106-$8,950) ($42,706-$44,192) ($17,311-$73,573)
OtherTx $0 $0 $5,130 $5,287 $7,664 $7,898 $12,794 $13,184
   ($5,021-$5,239) ($2,115-$8,459) ($7,501-$7,862) ($3,159-$12,636) ($12,523-$13,065) ($5,274-$21,095)
Alternate model         
AA $504 $470 $3,025 $2,819 $4,519 $4,212 $8,049 $7,501
($498-$509) ($294-$704) ($2,995-$3,055) ($1,762-$4,229) ($4,474-$4,564) ($2,632-$6,318) ($7,968-$8,128) ($4,688-$11,251)
AAwd $0 $0 $1,541 $1,410 $2,303 $2,106 $3,844 $3,515
   ($1,529-$1,554) ($1,057-$2,115) ($2,283-$2,321) ($1,580-$3,159) ($3,812-$3,874) ($2,637-$5,273)
Abiraterone $69,512 $65,531 $7,103 $6,697 $10,611 $10,003 $87,227 $82,231
($68,593-$70,431) ($31,041-$120,715) ($7,009-$7,197) ($3,172-$12,335) ($10,470-$10,751) ($4,738-$18,428) ($86,073-$88,381) ($38,952-$151,478)
Docetaxel $6,143 $6,118 $2,477 $2,467 $3,701 $3,686 $12,321 $12,271
($6,083-$6,203) ($6,118-$6,992) ($2,453-$2,501) ($2,467-$2,819) ($3,665-$3,737) ($3,686-$4,212) ($12,201-$12,441) ($12,271-$14,024)
Cabazitaxel $49,131 $43,125 $2,007 $1,762 $2,999 $2,632 $54,138 $47,519
($48,366-$49,895) ($34,500-$60,375) ($1,977-$2,038) ($1,409-$2,467) ($2,952-$3,046) ($2,106-$3,685) ($53,295-$54,980) ($38,016-$66,528)
OtherTx $0 $0 $5,300 $5,639 $7,918 $8,424 $13,217 $14,063
   ($5,186-$5,414) ($2,467-$8,459) ($7,747-$8,087) ($3,685-12,636) ($12,933-$13,501) ($6,153-$21,095)
  1. Abbreviations: 95%CI 95% confidence interval, IQR Interquartile range, AA Anti-androgen, AAwd Anti-androgen withdrawal, OtherTx Other treatments.
  2. *assuming that only 95% of patients have received medication for medical castration; **assuming that only 90% of patients have received bone-targeted therapy.