Figure 1

Primary treatment sequence over mCRPC period: A) Current model ; B) Alternate model. Ovals/circles indicate treatment-related states. Straight arrows connecting two different treatment-related states show that the patient may move to a subsequent therapy state during each monthly cycle. Short curved arrows leading from a therapy state to itself indicate that the patient may remain in that state in successive cycles. Abbreviations: mCRPC = start of mCRPC state; 2nd HT = second line hormone therapy; 2nd HT wd = second line hormone therapy withdrawal; 1st chemo = first-line chemotherapy; 3rd HT = third line hormone therapy; 2nd chemo = second-line chemotherapy; OtherTx = Other treatments state; AA = anti-androgen state; AAwd = anti-androgen withdrawal state; *Death state integrates both prostate cancer related and non-related causes of death.