
Weight bands


Age (years)

35.9 kg

69.9 kg

1013.9 kg

1419.9 kg

2024.9 kg

2534.9 kg

35+ kg


0.5

0.246

0.754

0.000

0.000

0.000

0.000

0.000

1

0.001

0.908

0.091

0.000

0.000

0.000

0.000

2

0.000

0.285

0.706

0.009

0.000

0.000

0.000

3

0.000

0.044

0.842

0.113

0.000

0.000

0.000

4

0.000

0.003

0.593

0.398

0.005

0.000

0.000

5

0.000

0.000

0.262

0.696

0.039

0.003

0.000

6

0.000

0.000

0.070

0.779

0.135

0.016

0.001

7

0.000

0.000

0.011

0.638

0.292

0.057

0.003

8

0.000

0.000

0.001

0.403

0.439

0.147

0.010

9

0.000

0.000

0.000

0.197

0.481

0.293

0.029

10

0.000

0.000

0.000

0.073

0.390

0.464

0.073

11

0.000

0.000

0.000

0.019

0.234

0.586

0.162

12

0.000

0.000

0.000

0.003

0.096

0.591

0.310

13

0.000

0.000

0.000

0.000

0.023

0.465

0.512


Abbreviation: kg kilogram.
 Weightbyage standards were tabulated from the WHO Child Growth Standards for children <5 years and from the CDC Growth Charts for children ages ≥5 years [30, 31]. The equations used to generate these agespecific weight distributions rely on the LambdaMuSigma parameters: the median (M) weight, the generalized coefficient of variation (S), and the power in the BoxCox transformation (L) [32, 34]. To account for lower weights among HIVinfected children relative to the general population of same age, the agespecific weight distributions for HIVinfected children were shifted to the 1.5 zscore of the general population distributions [33]. The HIVinfected median weightforage values (M_{HIV}) were calculated at halfyear intervals, where M_{HIV} was equal to the value M*(1 + LSZ)^{(1/L)}. The coefficient of variation (S_{HIV}) was assumed to be equal to that of children of the same age in the general population. Zscores for the upper and lower bounds of the WHOspecified weight intervals for ARV dosing (3 kg, 5.9 kg, 6 kg, 9.9 kg, 10 kg, 13.9 kg, 14 kg, 19.9 kg, 20 kg, 24.9 kg, 25 kg, and 34.9 kg) were calculated by gender for children ages 0–13 years old, as follows: the zscore of the bound of interest, X, equals ((X/M_{HIV})^{L} 1)/L*S_{HIV}. The Norm.S.Dist(z,1) Excel function was used to convert zscores into cumulative probability estimates. The probability of being in each weight band (by age and gender) was calculated as the cumulative probability of being below the upper bound of the weight band subtracted by the cumulative probability of being below the lower bound of the weight band (or the area under the curve within the upper and lower bounds). Results shown above assume an equal proportion of males and females.