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Table 1 Weight-based dosing recommendations for currently recommended and commonly used antiretroviral drugs [7, 28]

From: Estimating age-based antiretroviral therapy costs for HIV-infected children in resource-limited settings based on World Health Organization weight-based dosing recommendations

  WHO dosing recommendations by weight band
Medication (strength) 3-5.9 kg 6-9.9 kg 10-13.9 kg 14-19.9 kg 20-24.9 kg 25-34.9 kg 35+ kg
ABC (20 mg/ml) 3 ml bid 4 ml bid 6ml bid - - - -
ABC (60 mg) 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
ABC (300 mg) - - - - - 1 tab bid 1 tab bid
d4T (1 mg/ml) 6 ml bid 9 ml bid - - - - -
d4T (15 mg) - - 1 tab bid - - - -
d4T (20 mg) - - - 1 tab bid 1 tab bid - -
d4T (30 mg) - - - - - 1 tab bid 1 tab bid
3TC (10 mg/ml) 3 ml bid 4 ml bid 6 ml bid - - - -
3TC (150 mg) - - - 0.5 tab bid 1 tab am + 0.5 tab pm 1 tab bid 1 tab bid
EFV (200 mg) NR NR 1 cap qd (≥3yrs only) 1.5 cap qd 1.5 cap qd 2 cap qd -
EFV (600 mg) - - - - - - 1 tab qd
LPV/r (80/20 mg/ml) 1 ml bid 1.5 ml bid 2ml bid 2.5 ml bid 3 ml bid - -
LPV/r (100/25 mg) NR NR 2 tab am + 1 tab pm 2 tab bid 2 tab bid 3 tab bid -
LPV/r (200/50 mg) - - - - - - 2 tab bid
NVP (10 mg/ml) 5 ml bid 8ml bid 10 ml bid - - - -
NVP (50 mg) 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
NVP (200 mg) - - - - - 1 tab bid 1 tab bid
ZDV (10 mg/ml) 6 ml bid 9 ml bid 12 ml bid - - - -
ZDV (60 mg) 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
ZDV (300 mg) - - - - - 1 tab bid 1 tab bid
ZDV/3TCA (60 mg/30 mg) 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
ZDV/3TCA (300 mg/150 mg) - - - - - 1 tab bid 1 tab bid
ZDV/3TC/NVPB (60 mg/30 mg/50 mg) 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
ZDV/3TC/NVPB (300 mg/150 mg/200 mg) - - - - - 1 tab bid 1 tab bid
d4T/3TC (6 mg/30 mg)C 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
d4T/3TCC (30 mg/150 mg) - - - - - 1 tab bid 1 tab bid
d4T/3TC/NVPD (6 mg/30 mg/50 mg) 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
d4T/3TC/NVPD (30 mg/150 mg/200 mg) - - - - - 1 tab bid 1 tab bid
ABC/3TCE (60 mg/30 mg) 1 tab bid 1.5 tab bid 2 tab bid 2.5 tab bid 3 tab bid - -
ABC/3TCE (600 mg/300 mg) - - - - - 0.5 tab bid 0.5 tab bid
  1. Abbreviations: ABC abacavir, d4T stavudine, 3TC lamivudine, EFV efavirenz, LPV/r lopinavir/ritonavir, NVP nevirapine, ZDV zidovudine, mg milligrams, ml milliliter, bid twice daily, qd once daily, NR not recommended, tab tablet, cap capsule, kg kilogram.
  2. A. Pediatric tablet is scored and can be split. Can be crushed and contents mixed with a small amount of water or food and taken immediately.
  3. B. Pediatric tablet is dispersible and may be split. Can be dispersed into a small volume of water and mixed into a small amount of food and taken immediately.
  4. C. Pediatric tablet is dispersible and crushable, can be split.
  5. D. Pediatric tablet is dispersible and crushable, can be split. If unable to swallow, disperse 1 tablet in 2 teaspoons of water.
  6. E. Pediatric tablet is scored and can be split. Can be crushed and contents mixed with a small amount of water or food and taken immediately.