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Table 2 Total costs, LYs and QALYs of all interventions for HBeAg positive CHB patients aged 30 years old and above

From: A cost-utility analysis of drug treatments in patients with HBeAg-positive chronic hepatitis B in Thailand

Interventions Total costs (THB)§ LYs QALYs Incremental cost (THB) Incremental QALYs ICER per QALY gained
First drug (Second drug) Third drug
1. Generic lamivudine (tenofovir) 456,000 20.87 13.66 -72,000 5.03 Dominant*
2. Generic lamivudine (tenofovir) 490,000 20.87 13.66 -38,000 5.03 Dominant*
3. Tenofovir monotherapy 501,000 20.89 13.67 -26,000 5.04 Dominant*
4. Palliative care 527,000 13.13 8.63 - - -
5. Original lamivudine (tenofovir) 937,000 20.87 13.66 409,000 5.03 81,000
6. Pegylated interferon (original lamivudine) tenofovir 953,000 20.89 13.67 426,000 5.05 84,000
7. Original lamivudine (tenofovir) 971,000 20.87 13.66 444,000 5.03 88,000
8. Generic lamivudine (adefovir) 982,000 20.87 13.66 454,000 5.03 90,000
9. Pegylated interferon (tenofovir) 1,057,000 20.91 13.69 530,000 5.06 105,000
10. Telbivudine (tenofovir) 1,091,000 20.90 13.68 564,000 5.05 112,000
11. Generic lamivudine (adefovir) 1,134,000 20.87 13.66 606,000 5.03 121,000
12. Telbivudine (tenofovir) 1,134,000 20.87 13.66 606,000 5.03 121,000
13. Pegylated interferon (original lamivudine) tenofovir 1,325,000 20.89 13.67 798,000 5.05 158,000
14. Adefovir (generic lamivudine) 1,364,000 20.85 13.64 837,000 5.01 167,000
15. Pegylated interferon (lamivudine) adefovir 1,371,000 20.89 13.67 844,000 5.05 167,000
16. Telbivudine (adefovir) 1,429,000 20.90 13.68 902,000 5.05 178,000
17. Pegylated interferon (telbivudine) tenofovir 1,442,000 20.92 13.69 915,000 5.06 181,000
18. Original lamivudine (adefovir) 1,463,000 20.87 13.66 936,000 5.03 186,000
19. Entecavir (tenofovir) 1,519,000 20.88 13.67 991,000 5.04 197,000
20. Entecavir (adefovir) 1,536,000 20.88 13.67 1,009,000 5.04 200,000
21. Adefovir (original lamivudine) 1,564,000 20.85 13.64 1,037,000 5.01 207,000
22. Original lamivudine (adefovir) 1,616,000 20.87 13.66 1,088,000 5.03 216,000
23. Pegylated interferon (adefovir) generic lamivudine 1,648,000 20.88 13.66 1,120,000 5.04 222,000
24. Telbivudine (adefovir) 1,657,000 20.90 13.68 1,130,000 5.05 224,000
25. Pegylated interferon (telbivudine) adefovir 1,710,000 20.92 13.69 1,182,000 5.06 233,000
26. Pegylated interferon (original lamivudine) adefovir 1,744,000 20.89 13.67 1,216,000 5.05 241,000
27. Pegylated interferon (entecavir) tenofovir 1,771,000 20.90 13.68 1,243,000 5.05 246,000
28. Pegylated interferon (entecavir) adefovir 1,785,000 20.90 13.68 1,257,000 5.05 249,000
29. Pegylated interferon (adefovir) original lamivudine 1,812,000 20.88 13.66 1,284,000 5.04 255,000
  1. Scenario 1: Adding drug when drug resistance occurred; Scenario 2: Adding drug based on the road map guideline.
  2. §total costs are calculated in 2010 THB and rounded up to nearest 1,000 THB.
  3. *Negative ICER due to higher effectiveness and lower costs of intervention compared with palliative care.