Utilisation of rosiglitazone and pioglitazone by the Australian population between 2004–2012. The drop-down lines indicate months of drug safety warnings issued. Notes: Rosiglitazone warnings: EMA1-Reminded the risk of rosiglitazone in patients with cardiac failure and other cardiac disorders including myocardial infarction. FDA1-Advised to evaluate the antidiabetic treatment options other than rosiglitazone in patients who have underlying heart disease and high risk of heart attack. FDA2-Adds box warnings for heart-related risks of rosiglitazone. EMA2-Suggested that rosiglitazone should only be used after careful evaluation of ischemic heart disease. TGA1-dvised that rosiglitazone should not be prescribed for patients with known ischemic heart disease or at high risk for ischemic heart disease. EMA3-Suggested that rosiglitazone must not be used in patients with an acute coronary disease. EMA4-Recommended suspension of all rosiglitazone-containing products. FDA3-Restricts access to rosiglitazone due to an elevated risk of cardiovascular events. TGA3-Reinforced that rosiglitazone should not be used in patients with known ischemic heart disease. Pioglitazone warnings: FDA-Announced the warnings on a possibly increased risk of bladder cancer in patients who used rosiglitazone for longer than one year. TGA-Advised the prescribers that use of pioglitazone for more than a year may be associated with an increased risk of bladder cancer. EMA-Recommends new contraindications and warnings for pioglitazone to reduce small increased risk of bladder cancer. TGA = Therapeutic Good Administration; EMA = European Medicines Agency; FDA = U.S. Food and Drug Administration.