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Table 1 Definitions of test and performance characteristics

From: Technical evaluation of methods for identifying chemotherapy-induced febrile neutropenia in healthcare claims databases

 

Gold standard

 
  

Yes

No

 
 

Yes

X

Y

 
 

No

Z

K

 

Test/Performance Characteristic

 

Definition

Explanation

 Patient Classification, %

   

  True-Positive

 

X / (No. of Patients) × 100%

 

  False-Positive

 

Y / (No. of Patients) × 100%

 

  True-Negative

 

K / (No. of Patients) × 100%

 

  False-Negative

 

Z / (No. of Patients) × 100%

 

 Sensitivity, %

 

X / (X+Z) × 100%

% of FN hospitalizations correctly identified by claims-based definition

 Specificity, %

 

K / (Y+K) × 100%

% of non-FN hospitalizations correctly identified by claims-based definition

 Positive Predictive Value (PPV), %

 

X / (X+Y) × 100%

% of hosp. identified as FN hosp. by claims-based definition that were true-positives

 Negative Predictive Value (NPV), %

 

K / (Z+K) × 100%

% of hosp. identified as non-FN hosp. by claims-based definition that were true-negatives

 Accuracy, %

 

(X+K) / (No. of Patients) × 100%

% of all hospitalizations that were true-positives and true-negatives

 Likelihood ratio positive (LR+)

 

[X/(X+Z)] / [1-K/(Y+K)]

Odds of hosp. being an FN hosp. when claims-based algorithm is positive

 Likelihood ratio negative (LR-)

 

[1-X/(X+Z)] / [K/(Y+K)]

Odds of hosp. being a non-FN hosp. when claims-based algorithm is negative

  1. FN: febrile neutropenia.