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Table 4 Interventions with combination messages (to reduce and increase medicines use)

From: Bridging evidence-practice gaps: improving use of medicines in elderly Australian veterans

Intervention number and topic (number of veterans targeted) Targeted therapy Proportion of veterans on targeted therapy at baseline (%) 24 month pre-intervention trend Intervention effect (%) 20 month post intervention trend Estimated number with changed behaviour as a result of intervention; sustained over two years post intervention
10: Constipation: a quality of life issue for veteran patients (n = 29231) Increase use of osmotic laxatives 1.5% Trend increasing 0.7% per month 1.8% (p = 0.11) Trend increasing at greater rate 1.2% per month (p = 0.002) 2047 (825 additional people on osmotic laxatives, 410 additional people on contact laxatives and 690 less people on bulk laxatives)
Decrease use of contact laxatives 2.5% Trend increasing 0.2% per month 3.0% (p = 0.0007) Trend still increasing (non-significant to prior) 0.2% per month (p = 0.87)
Increase use of bulk laxatives 1.9% Trend decreasing − 0.7% per month 0.8% (p = 0.34) Trend now decreasing at greater rate − 0.9% per month (p = 0.04)
13: Clopidogrel (n = 16867) Increase use of clopidogrel with aspirin 1.5% Trend increasing 0.8% per month 3.0% (p = 0.018) Trend still increasing (non-significant to prior) 0.7% per month (p = 0.4) 1114 (825 now on aspirin with clopidogrel, 289 no longer on NSAIDs with clopidogrel)
Reduce concurrent use of clopidogrel with NSAIDs 1% Trend decreasing − 0.3% per month −5.3% (p = 0.002) Trend still increasing (non-significant to prior) 0.1% per month (p = 0.3)