Evaluating adverse drug event reporting in administrative data from emergency departments: a validation study

Table 1 Examples of ICD-10 codes indicating adverse drug events within each code category

Code Category	Definition	Number of codes in category	Examples
			Code	Code description*
A1	The ICD-10 code description includes the phrase “induced by medication/drug.”	114	J70.2	Acute drug-induced interstitial lung disorders
A2	The ICD-10 code description includes the phrase “induced by medication or other causes.”	81	142.7	Cardiomyopathy due to drugs and other external agents
A2		81	T88.7	Unspecified adverse event of drug or medicament
B1	The ICD-10 code dictionary includes the phrase “poisoning by medication.”	134	T36	Poisoning by systemic antibiotics
B2	The ICD-10 code dictionary includes the phrase “poisoning by or harmful use of medication or other causes.”	19	X44	Accidental poisoning by, and exposure to, other and unspecified drugs, medicaments and biological substances
C^§	Adverse drug event deemed to be very likely although the ICD-10 code description does not refer to a drug.	32	L51.2	Toxic epidermal necrolysis
D^§	Adverse drug event deemed to be likely although the ICD-10 code description does not refer to a drug.	86	N17	Acute renal failure with tubular necrosis
E^§	Adverse drug event deemed to be possible although the ICD-10 code dictionary does not refer to a drug.	85	K25	Gastric ulcer
			Y66	Non administration of surgical and medical care

*The code descriptions are from the ICD-10 coding dictionary [29].
^§The likelihood of the ICD-10 code indicating an adverse drug event was adapted from Stausberg et al., [27, 28] and where missing, was determined by two investigators who arrived at their ratings independently, and subsequently obtained consensus through discussion (CH and JS).

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