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Table 6 Estimated preference weights and Willingness to Pay (WTP) in a propensity score matched subset of the public and patients

From: Genomic testing to determine drug response: measuring preferences of the public and patients using Discrete Choice Experiment (DCE)

  The public, scenario A   (N = 83) patients, scenario A   (N = 38) P-value for difference
  Coefficient (s.e.) OR MWTP Coefficient (s.e.) OR MWTP  
Untreated responders &        
   5% 0.248 (0.0687)** 1.58 2,658 0.8794 (0.1068)** 5.23 12,820 <.0001
   20% 0.0528 (0.0676) 1.30 1517 0.0442 (0.1068) 2.27 6,346 0.6084
   35% −0.0942 (0.0702) 1.12 657 −0.1492 (0.1133) 1.87 4,847 0.6582
   50% −0.2066 1 Ref −0.7744 1 Ref  
Unnecessary treatment of non-responders        
   5% 0.1867 (0.0679)** 1.39 1,919 0.1083 (0.1083) 1.59 3,580 0.9663
   20% 0.0134 (0.0697) 1.17 906 0.2391 (0.1112)* 1.81 4,594 0.1598
   35% −0.0586 (0.0683) 1.09 485 0.0062 (0.1088) 1.43 2,789 0.657
   50% −0.1415 1 Ref −0.3526 1 Ref  
Severity of side effects        
   Mild 0.2712 (0.0524)** 2.10 4,327 0.3084 (0.0839)** 2.09 5,716 0.7
   Moderate 0.1976 (0.053)** 1.95 3,897 0.1206 (0.0871) 1.73 4,260 0.3008
   Severe −0.4688 1 Ref −0.4290 1 Ref  
Likelihood of side effects        
   5% 0.2645 (0.0521)** 1.65 2,937 0.2735 (0.0838)* 1.60 3,650 0.8119
   50% −0.0267 (0.0529) 1.24 1,235 −0.0762 (0.0864) 1.13 939 0.5678
   95% −0.2378 1 Ref −0.1973 1 Ref  
Genetic test turnaround time        
   2 days 0.1673 (0.0531)** 1.40 1,978 0.0174 (0.087) 1.15 1,117 0.2467
   7 days 0.0036 (0.0521) 1.19 1,021 0.1093 (0.0857) 1.27 1,829 0.5259
   12 days −0.1709 1 Ref −0.1267 1 Ref  
Genetic test procedure        
   Mouth swab 0.2591 (0.0783)** 1.75 3,258 0.3918 (0.1239)* 2.43 6,881 0.4303
   Blood sample 0.3382 (0.0825)** 1.89 3,720 0.1168 (0.1322) 1.85 4,750 0.2508
   Tumor biopsy −0.04 (0.0828) 1.29 1,509 −0.0829 (0.1342) 1.51 3,202 0.7787
   Bone marrow biopsy −0.2593 (0.081)** 1.04 226 0.0702 (0.1286) 1.76 4,388 0.1121
   Liver biopsy −0.2980 1 Ref −0.4959 1 Ref  
Neither (No test) −1.0346 (0.1037)** 0.36 −6,050 −0.1185 (0.1382) 0.89 −919 0.0002
Genetic test cost −0.00017 (0.00007)*   Ref −0.00013 (0.00012)   Ref 0.1901
   McFadden’s LRI 0.20       
   Adjusted Estrella 0.35       
   Log-likelihood Ratio 832.8       
   AIC 3493       
   Schwartz Criterion 3694       
  1. ** p-value < 0.01; * p-value < 0.05.
  2. &1-Sensitivity.
  3. 1-specificity.