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Table 5 Estimated preference weights and Willingness to Pay (WTP) in samples from the public

From: Genomic testing to determine drug response: measuring preferences of the public and patients using Discrete Choice Experiment (DCE)

  The public, scenario A (N = 533)   The public, scenario B (N = 525)   P-value for difference
  Coefficient (s.e.) OR MWTP Coefficient (s.e.) OR MWTP  
Untreated responders &        
   5% 0.1748 (0.0266)** 1.41 1,331 0.2577 (0.0270)** 1.65 1,344 0.0241
   20% 0.0367 (0.0265) 1.23 796 0.0324 (0.0274) 1.32 740 0.8487
   35% −0.0429 (0.0276) 1.13 487 −0.0465 (0.0285) 1.22 528 0.9315
   50% −0.1686 (0.0466) 1 Ref −0.2436 (0.0479)** 1 Ref  
Unnecessary treatment of non-responders        
   5% 0.1008 (0.0268)** 1.24 827 0.2452 (0.0270)** 1.50 1,080 0.0004
   20% 0.0065 (0.0274) 1.13 461 0.0377 (0.0288) 1.22 524 0.6691
   35% 0.0051 (0.0272) 1.12 456 −0.1251 (0.0281)** 1.03 88 0.0115
   50% −0.1124 (0.0470) 1 Ref −0.1578 (0.0485)** 1 Ref  
Severity of side effects        
   Mild 0.3319 (0.0205)** 2.10 2,882 0.3295 (0.0211)** 2.24 2,165 0.3838
   Moderate 0.0798 (0.0210)** 1.63 1,905 0.1484 (0.0217)** 1.87 1,679 0.0621
   Severe −0.4117 (0.0293)** 1 Ref −0.4779 (0.0303)** 1 Ref  
Likelihood of side effects        
   5% 0.2490 (0.0204)** 1.62 1,861 0.2622 (0.0213)** 1.75 1,497 0.2245
   50% −0.0179 (0.0209) 1.24 826 0.0340 (0.0214) 1.39 885 0.2261
   95% −0.2311 (0.0292)** 1 Ref −0.2962 (0.0302)** 1 Ref  
Genetic test turnaround time        
   2 days 0.1213 (0.0210)** 1.26 911 0.1266 (0.213)** 1.27 650 0.4533
   7 days −0.0076 (0.0208) 1.11 411 −0.0107 (0.0218) 1.11 282 0.5396
   12 days −0.1137 (0.0296)** 1 Ref −0.1159 (0.0305)** 1 Ref  
Genetic test procedure        
   Mouth swab 0.2962 (0.0304)** 1.75 2,162 0.3045 (0.0311)** 1.73 1,474 0.9942
   Blood sample 0.2863 (0.0320)** 1.73 2,124 0.3882 (0.0332)** 1.88 1,698 0.5738
   Tumor biopsy −0.0416 (0.0326) 1.25 853 −0.0809 (0.0332)** 1.18 440 0.8152
   Bone marrow biopsy −0.2792 (0.0321)** 0.98 −68 −0.3666 (0.0339)** 0.89 −325 0.6879
   Liver biopsy −0.2617 (0.0636)** 1 Ref −0.2452 (0.0675)** 1 Ref  
Neither (No test) −0.6323 (0.0379)** 0.53 −2,451 −0.4967 (0.0389)** 0.61 −1,332 0.0169
Genetic test cost −0.00026 (0.00003)**   Ref −0.00037 (0.00003)**   Ref 0.0091
   McFadden’s LRI 0.17       
   Adjusted Estrella 0.33       
   Log-likelihood Ratio 6216.5       
   AIC 31050       
   Schwartz Criterion 31329       
  1. ** p-value < 0.01.
  2. &1-Sensitivity.
  3. 1-specificity.