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Table 2 Multivariate analysis of patients’ characteristics and started on metformin (Yes/No)

From: Guidelines adherence in the treatment of patients with newly diagnosed type 2 diabetes: a historical cohort comparing the use of metformin in Quebec pre and post-Canadian Diabetes Association guidelines

 

No (%) of patients or mean ± SD

Multivariate analysis*

 

Yes

No

OR (95% CI)

p value

Patient characteristics

n = 1177

n = 102

  

Gender

    

• Male

582 (49.5)

47 (46.1)

1.00 [Reference]

 

• Female

595 (50.6)

55 (53.9)

0.85 (0.55-1.32)

0.48

Age

    

• ≥65

649 (55.1)

72 (70.6)

1.0 [Reference]

 

• <65

528 (44.9)

30 (29.4)

1.64 (1.09-2.48)

0.02

Co-morbidities

    

Cardiovascular

    

• No

1101 (93.5)

93 (91.2)

1.00 [Reference]

 

• Yes

76 (6.5)

9 (8.8)

0.78 (0.37-1.66)

0.52

Renal

    

• No

1167 (99.1)

95 (93.1)

1.00 [Reference]

 

• Yes

10 (0.9)

7 (6.9)

0.14 (0.05-0.40)

<0.0001

Drugs

Number of OHA

    

• ≥2

93 (7.9)

9 (8.8)

1.00 [Reference]

0.83

• 1

1084 (92.1)

93 (91.2)

0.91 (0.37-2.19)

 

Physician characteristics

n=95

n=73

  

MD gender

    

• Male

59 (54.1)

34 (63.0)

1.00 [Reference]

 

• Female

50 (45.9)

20 (37.0)

1.21 (0.66-2.23)

0.53

Practice experience (in years) (mean, SD)

21.9 (8.2)

24 (7.8)

1.00 (0.96-1.05)

0.94

MD evidence scale (mean, SD)

n=90

n=52

  

• <20

22 (24.4)

14 (26.9)

1.00 [Reference]

 

• 20-23

53 (58.9)

31 (59.6)

0.71 (0.38-1.34)

0.29

• >23

15 (16.7)

7 (13.5)

1.16 (0.55-2.46)

0.69

Evidence guidelines †

2008 CDA guidelines

    

• Pre

601 (51.1)

69 (67.7)

1.00 [Reference]

 

• Post

576 (48.9)

33 (32.4)

1.86 (1.20-2.90)

0.01

  1. Note: OHA Oral hypoglycemic agent, CDA Canadian Diabetes Association.
  2. *Multivariate analysis done for patients’ gender, age and co-morbidities, guidelines, MD evidence scale, gender, practice experience and drugs.
  3. †Model cannot converge when an interaction term involving guideline and MD evidence scale (categorical) were included.