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Table 2 Occurrence and preventability of ADEs among surgical, nonsurgical and all inpatients

From: Occurrence and preventability of adverse drug events in surgical patients: a systematic review of literature

Population

Data

Unit

Classen 1991[17]

Bates 1993[14]

Bates 1995[15]

Lazarus 2003[18]

Berga Cullere 2008[16]

Morimoto 2011[19]

Surgical

Records

Admissions

23,458*

151‡

493‡

-

-

1,469

Patients

-

-

-

-

775

-

Patient-days

-

1,066

4,339

-

-

-

No. ADEs

ADEs

480

5

39*

-

-

407

Patients with ADE

-

-

-

-

69

-

Occurrence ADEs (95% CI)

/100 admissions

2.0 (1.9-2.2)*

3.3 (0.5-6.2)‡

7.9 (5.5-10.3)‡

-

-

27.7 (25.4-30.0)

/100 patients

-

-

-

-

8.9 (6.9-10.9)*

-

/1,000 patient-days

-

4.7 (1.5-10.9)*

8.9 (6.1-11.7)

-

-

-

Preventability ADEs

 

-

-

7/39 (18% (5.9-30.0))*

-

37/69 (54% (41.9-65.4) of the ADE patients)

-

Nonsurgical

Records

Admissions

8,064*

142‡

527‡

-

-

1,531

Patients

-

-

-

-

775

-

Patient-days

-

1,003

11,499

-

-

-

No. ADEs

ADEs

251

13

122*

-

-

504

Patients with ADE

-

-

-

-

90

-

Occurrence ADEs (95% CI)

/100 admissions

3.1 (2.7-3.5)*

9.2 (4.4-13.9)‡

23.1 (19.5-26.8)‡

-

-

32.9 (30.6-35.3)

/100 patients

-

-

-

-

11.6 (9.4-13.9)*

-

/1,000 patient-days

-

13.0 (6.9-22.2)*

10.6 (8.7-12.4)

-

-

-

Preventability ADEs

 

-

-

34/122 (28% (19.9-35.8))*

-

45/90 (50% (39.7-60.3) of the ADE patients)

-

Overall

Records

Admissions

36,653

420

4,031

4,320 †

-

3,459

Patients

-

-

-

-

1,550

-

Patient-days

-

2,967

21,412

-

-

-

No. ADEs

ADEs

731

27

247

98†

194

1,010

Patients with ADE

-

-

-

-

-

-

Occurrence ADEs (95% CI)

/100 admissions

2.0 (1.9-2.1)*

6.4 (4.1-8.8)*

6.1 (5.4-6.9)

2.3 (1.8-2.7)†

-

29.2 (27.7-30.7)

/100 patients

-

-

-

-

12.5 (10.9-14.2)*

-

/1,000 patient-days

-

-

-

-

-

-

Preventability ADEs

 

-

15/27 (56%)

70/247 (28%)

-

91/194 (47%)

141/1010 (14%)

  1. *Calculated from rough data; ‡estimated based on rough data i.e. the numbers of admissions were calculated by dividing the patient-days by the length of hospital stay; 95% CI indicates the 95% confidence interval; †this study solely included surgical patients.