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Table 3 Intensity of pharmacological therapy in T2DM patients receiving cardiovascular prevention by CVD status

From: Pharmacological primary and secondary cardiovascular prevention among diabetic patients in a multiethnic general practice population: still room for improvements

Characteristicsa

Valid cases

Intensity of therapy

One agent

Two agents

Three or more agents

Primary prevention of CVD

   

Proportions of patients on glucose lowering therapy achieving and not achieving treatment target (%, 95 % CI)

HbA1c ≤ 7.5%

595

63.9 (59.9-67.6)

34.6 (30.9-38.5)

1.5 (0.8-2.9)

HbA1c > 7.5%

304

43.4 (38.0-49.9)

51.0 (45.4-56.6)

5.6 (3.5-8.8)

P < 0.001b

    

Proportions of patients on anti-hypertensive therapy achieving and not achieving treatment target (%, 95% CI)

SBP ≤ 140 mmHg

414

43.7 (39.0-48.5)

29.0 (24.8-33.5)

27.3 (23.2-31.8)

SBP > 140 mmHg

258

35.3 (29.7-41.3)

28.3 (23.1-34.1)

36.4 (30.7-42.3)

P=0.028b

    

DBP ≤ 85 mmHg

499

41.1 (36.9-45.5)

28.7 (24.9-32.8)

30.3 (26.4-34.4)

DBP > 85 mmHg

172

39.0 (32.0-46.4)

28.5 (22.2-35.7)

32.6 (26.0-39.9)

P=0.834b

    

Secondary prevention of CVD

   

Proportions of patients on glucose lowering therapy achieving and not achieving treatment target (%, 95% CI)

HbA1c ≤ 7.5%

183

58.5 (51.2-65.4)

37.7 (31.4-44.9)

3.8 (1.7-7.8)

HbA1c > 7.5%

97

48.5 (38.8-58.3)

47.4 (37.8-57.3)

4.1 (1.3-10.5)

P=0.269b

    

Proportions of patients on anti-hypertensive therapy achieving and not achieving treatment target (%, 95% CI)

SBP ≤ 140 mmHg

205

31.7 (25.7-38.4)

30.2 (24.4-36.9)

38.0 (31.7-44.9)

SBP > 140 mmHg

114

21.1 (14.5-29.5)

34.2 (26.1-43.3)

44.7 (35.9-53.9)

P=0.125b

    

DBP ≤ 85 mmHg

268

28.4 (23.3-34.0)

31.7 (26.4-37.5)

39.9 (34.2-45.9)

DBP > 85 mmHg

51

25.5 (15.4-39.0)

31.4 (20.3-45.1)

43.1 (30.5-56.7)

P=0.888b

    
  1. a CVD: cardiovascular disease. Treatment target for glucose-lowering therapy: HbA1c ≤ 7.5%, for antihypertensive therapy: systolic blood pressure (SBP) ≤ 140 mmHg and diastolic blood pressure (DBP) ≤ 85 mmHg.
  2. b P-values. Chi-square tests were applied to compare proportions of patients receiving one, two or three agents and between those achieving and not achieving the specific treatment targets.