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Table 1 NHI price list of antihypertensive drugs

From: Economic impact of switching to fixed-dose combination therapy for Japanese hypertensive patients: a retrospective cost analysis

 

Drug name

Listed price as of April 2012

Listed date of FDC drugs

ARB+HCTZ FDC

losartan (50 mg) + hydrochlorothiazide (6.25 mg)

146.4

December 2006

 

valsartan (80 mg) + hydrochlorothiazide (6.25 mg)

120.9

March 2009

 

candesartan (8 mg) + hydrochlorothiazide (6.25 mg)

143.6

March 2009

 

telmisartan (40 mg) + hydrochlorothiazide (6.25 mg)

137.9

June 2009

ARB+CCB FDC

valsartan (80 mg) + amlodipine (5 mg)

120.3

April 2010

 

olmesartan (20 mg) + azelnidipine (16 mg)

158.1

April 2010

 

candesartan (8 mg) + amlodipine (5 mg)

140.7

June 2010

 

telmisartan (40 mg) + amlodipine (5 mg)

133.2

September 2010

ARB

losartan (50 mg)

143.4

 
 

valsartan (80 mg)

114.8

 
 

candesartan (8 mg)

140.4

 
 

telmisartan (40 mg)

131.0

 
 

olmesartan (20 mg)

130.4

 

HCTZ

hydrochlorothiazide (25 mg)

5.6

 

CCB

amlodipine (5 mg)

23.1

 
 

azelnidipine (16 mg)

65.5

 
  1. ARB: angiotensin-receptor blocker, CCB: calcium-channel blocker, FDC: fixed-dose combination, HCTZ: hydrochlorothiazide.
  2. This table created from the NHI Drug Price List as of April 2012. When various doses of combination drugs exist, a major combination that is used frequently was selected. A generic version of losartan was listed in June 2012 at a price of 86.0 yen for a 50 mg tablet, about 60% of the cost of the original drug.