Performance of screening tests
|
gFOBT sensitivity for adenomas
|
11%
|
10%, 12%1
|
[13–21]
|
gFOBT sensitivity for CRC
|
36%
|
31%, 42%1
|
gFOBT specificity for adenomas and CRC
|
97%
|
96%, 98%
|
FIT sensitivity for adenomas
|
21%
|
19%, 22%1
|
[16, 22–32]
|
FIT sensitivity for CRC
|
71%
|
67%, 75%1
|
FIT specificity for adenomas and CRC
|
95%
|
94%, 96%
|
FSIG sensitivity for low-risk distal adenomas
|
65%
|
60%, 70%1
|
Expert opinion informed by [18, 20, 22]
|
FSIG sensitivity for intermediate/high-risk distal adenomas
|
74%
|
68%, 78%1
|
FSIG sensitivity for distal CRC
|
90%
|
85%, 95%1
|
FSIG specificity for distal adenomas and CRC
|
92%
|
90%, 95%
|
Uptake and compliance with screening, diagnosis and surveillance
|
gFOBT uptake
|
53%
|
32%, 70%
|
[34–37]
|
FIT uptake
|
53%
|
32%, 70%
|
FSIG uptake
|
39%
|
24%, 67%
|
[38–40]
|
COL compliance (diagnostic test or adenoma surveillance)
|
86%
|
-
|
[34, 35]
|
Performance of diagnostic tests and related parameters
|
COL sensitivity for low-risk adenomas
|
77%
|
-
|
[41, 42]
|
COL sensitivity for intermediate/high-risk adenomas
|
98%
|
-
|
COL sensitivity for CRC
|
98%
|
-
|
COL specificity for adenomas and CRC
|
97%
|
-
|
Expert opinion
|
CTC sensitivity for low-risk adenomas
|
53%
|
-
|
Expert opinion, informed by [43–46]
|
CTC sensitivity for intermediate/high-risk adenomas
|
85%
|
-
|
CTC sensitivity for CRC
|
85%
|
-
|
CTC specificity for adenomas and CRC
|
86%
|
-
|
Average number of adenomas removed per person
|
1.9
|
-
|
[47]
|
% of those with intermediate/high-risk adenomas removed in whom the adenoma was high-risk
|
29%
|
-
|
[34]
|
Harms of screening
|
FSIG probability of perforation (with or without polypectomy)
|
0.002%
|
-
|
[38]
|
FSIG probability of death following perforation
|
6.452%
|
-
|
[48]
|
Probability of (major) bleeding following FSIG
|
0.029%
|
-
|
[38]
|
COL probability of perforation (with polypectomy)
|
0.216%
|
-
|
[49]
|
COL probability of perforation (without polypectomy)
|
0.107%
|
-
|
COL probability of death following perforation
|
5.195%
|
-
|
[48]
|
Probability of (major) bleeding following COL
|
0.379%
|
-
|
[38]
|