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Table 3 Association between the occurrence of errors and general factors

From: Evaluation of drug administration errors in a teaching hospital

 

Administrations

Univariable analysis

Multivariable analysis*

Variable, n (%)

No error (N = 1086)

Error (N = 415)

OR [95% CI]†

Global P†

OR [95% CI]†

Global P†

Unit

   

0.64

  

Nephrology

230 (21.2)

54 (13.0)

1

   

Immunology-Cardiology

309 (28.5)

125 (30.1)

1.29 [0.37-4.52]

   

Vascular medical

266 (24.5)

113 (27.2)

1.56 [0.48-5.15]

   

Cardiovascular surgical

281 (25.9)

123 (29.6)

2.17 [0.65-7.23]

   

Day

   

0.104

  

Tuesday

192 (17.7)

56 (13.5)

1

   

Monday

175 (16.1)

51 (12.3)

1.52 [0.88-2.64]

   

Wednesday

199 (18.3)

73 (17.6)

1.43 [0.75-2.70]

   

Thursday

168 (15.5)

95 (22.9)

2.56 [1.33-4.92]

   

Friday

165 (15.2)

86 (20.7)

1.81 [0.95-3.45]

   

Saturday

187 (17.2)

54 (13.0)

1.69 [0.80-3.56]

   

Drug round

   

0.68

  

Noon

140 (12.9)

61 (14.7)

1

   

Morning

504 (46.4)

169 (40.7)

0.87 [0.59-1.29]

   

Night

442 (40.7)

185 (44.6)

0.77 [0.40-1.46]

   

Route

   

< .0001

 

< .0001

Oral

975 (89.8)

327 (78.8)

1

 

1

 

Injectable

81 (7.5)

50 (12.0)

2.42 [1.58-3.71]

 

3.30 [2.01-5.44]

 

Other

30 (2.8)

30 (7.2)

4.61 [2.39-8.89]

 

1.89 [0.72-4.94]

 

Drug ATC**

   

< .0001

 

< .0001

C

338 (31.1)

87 (21.0)

1

 

1

 

M

12 (1.1)

1 (0.2)

0.28 [0.03-2.32]

 

0.30 [0.04-2.53]

 

L

19 (1.7)

3 (0.7)

0.51 [0.13-1.93]

 

0.65 [0.17-2.48]

 

B

163 (15.0)

38 (9.2)

0.95 [0.59-1.53]

 

0.61 [0.36-1.03]

 

V

12 (1.1)

4 (1.0)

1.03 [0.25-4.25]

 

1.09 [0.26-4.54]

 

G

20 (1.8)

6 (1.4)

1.51 [0.52-4.42]

 

1.51 [0.51-4.42]

 

Others

3 (0.3)

2 (0.5)

1.60 [0.20-12.65]

 

1.47 [0.18-11.69]

 

A

184 (16.9)

86 (20.7)

1.69 [1.12-2.53]

 

1.61 [1.06-2.42]

 

N

185 (17.0)

94 (22.7)

1.94 [1.30-2.91]

 

2.01 [1.34-3.02]

 

J

100 (9.2)

50 (12.0)

2.61 [1.58-4.30]

 

1.96 [1.16-3.30]

 

H

24 (2.2)

16 (.3.9)

3.38 [1.58-7.26]

 

3.35 [1.57-7.18]

 

R

21 (1.9)

15 (3.6)

4.49 [1.86-10.85]

 

3.09 [1.06-8.99]

 

S

4 (0.4)

6 (1.4)

7.55 [1.51-37.74]

 

4.49 [0.68-29.66]

 

D

1 (0.1)

7 (1.7)

38.28 [3.85-380.34]

 

26.10 [2.17-314.30]

 

Unit-dose prepared by the pharmacy

   

0.22

  

No

216 (19.9)

98 (23.6)

1

   

Yes

870 (80.1)

317 (76.4)

0.81 [0.58-1.13]

   

Interruptions††

   

0.82

  

No

1037 (95.5)

339 (95.8)

1

   

Yes

49 (4.5)

15 (4.2)

0.92 [0.47-1.82]

   

Nurse's age‡‡

30 (27-35)

29 (27-33)

0.81 [0.62-1.06] ‡

0.127

  

Number of patient under nurse's care‡‡

8 (7-9)

9 (7-9)

1.21 [1.05-1.41] #

0.011

1.22 [1.04-1.42] #

0.013

Number of patient with drugs to be administered‡‡

6 (6-8)

7 (6-8)

1.04 [0.92-1.18] #

0.50

  
  1. * Terms not significant at the 5% level were removed (backward selection)
  2. † Derived from the logistic regression model with random effects
  3. ‡ OR for a 5-year increase
  4. # OR for a 1-patient increase
  5. ** ATC classification detailed in additional file
  6. †† Errors were observed on 354 administrations only (and not 415) due to omissions.
  7. ‡‡ Median (Q1-Q3)