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Table 2 Factors associated with HCV treatment initiation during the first three years of cohort follow-up; Univariate and multivariate analyses based on a logistic regression model (n = 600, ANRS CO13 HEPAVIH cohort.)

From: Engaging HIV-HCV co-infected patients in HCV treatment: the roles played by the prescribing physician and patients' beliefs (ANRS CO13 HEPAVIH cohort, France)

 

Univariate analysis

Multivariate analysis

 

p-value

OR (95% CI)

p-value

AOR (95% CI)

Female gender§

0.12

0.70 (0.45-1.09)

  

Agea§

0.06

0.73 (0.52-1.01)

0.04

0.69 (0.48-0.98)

Born outside France§

0.81

1.06 (0.64-1.76)

  

Secondary school certificate§

0.84

1.04 (0.68-1.60)

  

Having children§

0.05

0.63 (0.40-0.99)

  

Living in a couple§

0.91

1.02 (0.69-1.52)

  

Steady partner§

0.57

1.13 (0.75-1.70)

  

Employment§

0.85

1.04 (0.70-1.54)

  

Owner or renter of their house§

0.24

0.68 (0.36-1.28)

  

Good housing conditionsb§

0.53

1.19 (0.70-2.02)

  

Treated several times for depression§

0.97

0.99 (0.59-1.66)

  

Antidepressants use§

0.93

0.98 (0.59-1.61)

  

Harmful alcohol consumptionc§

0.25

1.40 (0.79-2.50)

  

Daily cannabis use§§

0.57

1.18 (0.67-2.06)

  

Cocaine use§§

0.75

1.12 (0.55-2.27)

  

Heroin use§§

0.54

1.45 (0.44-4.77)

  

More than 20 cigarettes consumed a day§§

0.88

1.04 (0.67-1.59)

  

Depressive symptomsd§

0.96

1.01 (0.65-1.56)

  

Number of self-reported symptoms§§

0.53

0.99 (0.97-1.02)

  

Receiving ART§

0.32

1.43 (0.70-2.89)

  

Number of years since first HIV positive testa

0.10

0.75 (0.53-1.06)

  

Number of years since first HCV positive testa§§

0.01

0.64 (0.47-0.88)

0.03

0.69 (0.49-0.97)

Patients negative perceptions about HCV treatment§§e

0.03

0.60 (0.38-0.94)

0.02

0.58 (0.37-0.92)

Severe fibrosis§f

< 10 -3

2.66 (1.74-4.09)

< 10 -3

2.87 (1.83-4.51)

CD4 cell count < 200§§

0.89

0.95 (0.48-1.89)

  

Undetectable HIV viral load§§

0.69

1.09 (0.72-1.65)

  

Patient high adherence as perceived by the physician§§

0.21

1.30 (0.87-1.94)

  

Followed up by a general practitioner§§

0.01

1.93 (1.20-3.12)

0.03

1.71 (1.06-2.75)

Patient alcohol problems as reported by the physician§§

0.75

0.92 (0.53-1.57)

  

Patient suicide attempts as reported by the physician§§

0.99

1.01 (0.44-2.28)

  

Patient history of multiple treatments for depression as reported by the physician§§

0.77

1.09 (0.62-1.90)

  

Liver biopsy at enrolment

< 10 -3

2.31 (1.54-3.45)

< 10 -3

2.20 (1.44-3.35)

  1. a Per ten year increase
  2. b Good housing conditions were defined as ranks 3 and 4 (quite or very comfortable vs. uncomfortable or quite uncomfortable) using a four-point Likert scale
  3. c Consumption of more than 90 alcohol units/month for men and 60 alcohol units/month for women
  4. d Patients were defined as having depressive symptoms if CES-D > 17 for men and > 23 for women.
  5. e Beliefs were measured on a 1-4 visual analogue scale. Believes HCV treatment to be non-effective (score 1) and associated with large number of side effects (score 4)
  6. f Severe fibrosis was defined according to Metavir score F3-F4 vs. F0-F1-F2.
  7. § < 5% of missing values estimated using multiple imputation
  8. §§ < 10% of missing values estimated using multiple imputation