| HCV treatment initiation |  |  | |
---|---|---|---|---|
 | NO % or median [IQR] N = 476 | Yes % or median [IQR] N = 124 | Total sample % or median [IQR] N = 600 | p-value§ |
Female gender | 34 | 27 | 33 | 0.12 |
Age | 44 [41-48] | 43 [41-47] | 44 [41-47] | 0.06 |
Born outside France | 19 | 20 | 19 | 0.79 |
HIV transmission group | Â | Â | Â | 0.51 |
   IV drug use | 63 | 64 | 63 |  |
   Heterosexual | 16 | 12 | 15 |  |
   Homosexual | 10 | 14 | 11 |  |
   Other or unknown | 11 | 10 | 10 |  |
HCV genotype | Â | Â | Â | 0.48 |
   1 or 4 | 66 | 72 | 67 |  |
   2 or 3 | 18 | 25 | 20 |  |
   5 | 1 | 0 | 1 |  |
   Unknown | 15 | 2 | 13 |  |
ASAT | 47 [34-71] | 52 [37-94] | 48 [35-74] | 0.06 |
ALAT | 52 [35-84] | 65 [42-91] | 56 [35-87] | 0.04 |
Previous exposure to IFN (not PEG) + ribavirine | 9 | 9 | 9 | 0.95 |
Severe fibrosis (Metavir F3 or F4) | 22 | 45 | 27 | < 10-3 |
Fibrosis score | Â | Â | Â | Â |
   F0-F1 | 59 | 40 | 55 | < 10-3 |
   F2 | 18 | 16 | 18 |  |
   F3 | 7 | 17 | 9 |  |
   F4 | 15 | 28 | 18 |  |
CD4 < 200/mm3 | 12 | 11 | 12 | 0.75 |
Undetectable HIV viral load | 62 | 60 | 81 | 0.69 |
Antidepressants use | 20 | 19 | 20 | 0.93 |
Harmful alcohol consumptiona | 11 | 15 | 12 | 0.25 |
Daily cannabis use | 15 | 18 | 16 | 0.52 |
Cocaine use | 8 | 10 | 9 | 0.59 |
Heroin use | 2 | 4 | 3 | 0.47 |
More than 20 cigarettes consumed per day | 32 | 33 | 32 | 0.88 |
Depressive symptomsb | 40 | 41 | 40 | 0.80 |
Number of self-reported symptoms | 7 [2-14] | 6 [2-14] | 7 [2-14] | 0.53 |
Receiving ART | 89 | 92 | 89 | 0.32 |
Number of years since first HIV positive test | 17 [13-20] | 16 [13-20] | 17 [13-20] | 0.11 |
Number of years since first HCV positive test | 11 [7-15] | 9 [4-13] | 10 [6-15] | 0.004 |
Patients negative beliefs HCV treatmentsc | 42 | 29 | 39 | 0.03 |
Patient- high adherence as perceived by the physician | 38 | 47 | 40 | 0.10 |
Patient- alcohol problems as perceived by the physician | 20 | 21 | 20 | 0.72 |
Patient- suicide attempts as reported by the physician | 8 | 8 | 8 | 0.99 |
Patient- history of multiple treatments for depression as reported by the physician | 19 | 20 | 19 | 0.77 |
Followed up by a general practitioner | 22 | 39 | 26 | 0.001 |
Liver biopsy at enrolment | 32 | 52 | 36 | < 10-3 |