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Table 2 Estimated annual net ingredient cost (NIC) savings € and % reduction as a proportion of overall NIC for effective and economical PPI prescribing (5 scenarios)

From: Proton pump inhibitors: potential cost reductions by applying prescribing guidelines

Scenarios (1 to 5) Cost Savings (NIC) % Overall (NIC)
1 PPI initiation (least expensive brand) €36,943,348 41.91
2 Therapeutic switching (cheaper brand, same dose) €29,568,475 33.54
3 Dose reduction (maintenance) €21,289,322 24.15
4 Therapeutic switching and dose reduction €40,505,013 45.95
5 Therapeutic substitution (H2 Antagonist) €34,991,569 39.69
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