Figure 1

Model structure: decision tree framework. The 10 mutually exclusive health outcomes for pneumococcal-related disease are represented by the 10 branches of the decision analytical model. Although the model is capable of estimating the disutility of long-term sequelae, these were not included in the presented analysis, due to a lack of accurate, region-specific data. AOM = acute otitis media, PCV-7 = 7-valent pneumococcal conjugate vaccine, PCV-13 = 13-valent pneumococcal conjugate vaccine, PHiD-CV = pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine.