Total AIDS cases reported in the clinical centre
| | |
0.94
| | |
0.79
| | |
0.93
|
0-250
|
1.00
| | |
1.00
| | |
1.00
| | |
251-500
|
1.10
|
(0.64-1.91)
| |
1.07
|
(0.50-2.29)
| |
1.07
|
(0.58-1.96)
| |
501-1000
|
1.03
|
(0.59-1.79)
| |
0.97
|
(0.45-2.11)
| |
0.99
|
(0.54-1.81)
| |
> 1000
|
0.93
|
(0.54-1.60)
| |
0.74
|
(0.35-1.59)
| |
1.18
|
(0.65-2.11)
| |
Type of clinical center
| | |
0.77
| | |
0.82
| | |
0.37
|
Non-teaching hospital
|
1.00
| | |
1.00
| | |
1.00
| | |
Teaching hospital
|
0.94
|
(0.62-1.42)
| |
1.07
|
(0.61-1.88)
| |
0.82
|
(0.53-1.27)
| |
Gender
| | |
0.41
| | |
0.69
| | |
0.48
|
Female
|
1.00
| | |
1.00
| | |
1.00
| | |
Male
|
0.89
|
(0.67-1.18)
| |
0.92
|
(0.62-1.37)
| |
0.87
|
(0.59-1.28)
| |
Age at therapy initiation/change (per 5 year increase)
|
1.00
|
(0.94-1.08)
|
0.90
|
0.99
|
(0.90-1.09)
|
0.82
|
1.02
|
(0.93-1.12)
|
0.70
|
Place of birth
| | |
0.36
| | |
0.97
| | |
0.14
|
Italy
|
1.00
| | |
1.00
| | |
1.00
| | |
Other countries
|
0.80
|
(0.51-1.28)
| |
1.01
|
(0.56-1.83)
| |
0.57
|
(0.28-1.19)
| |
Years of education
| | |
0.64
| | |
0.76
| | |
0.81
|
< = 8
|
1.00
| | |
1.00
| | |
1.00
| | |
9-13
|
1.14
|
(0.87-1.48)
| |
1.19
|
(0.82-1.73)
| |
1.11
|
(0.77-1.59)
| |
> 13
|
1.24
|
(0.75-2.05)
| |
1.23
|
(0.60-2.50)
| |
1.33
|
(0.67-2.64)
| |
Unknown
|
0.96
|
(0.70-1.32)
| |
0.97
|
(0.62-1.52)
| |
0.97
|
(0.63-1.49)
| |
Marital status
| | |
0.07
| | |
0.41
| | |
0.03
|
Never married
|
1.00
| | |
1.00
| | |
1.00
| | |
Married
|
1.25
|
(0.99-1.58)
| |
1.15
|
(0.83-1.59)
| |
1.43
|
(1.03-1.98)
| |
Occupational status
| | |
0.79
| | |
0.92
| | |
0.81
|
Unemployed
|
1.00
| | |
1.00
| | |
1.00
| | |
Employed
|
1.08
|
(0.83-1.41)
| |
1.08
|
(0.74-1.57)
| |
1.07
|
(0.74-1.55)
| |
Other
|
1.19
|
(0.65-2.17)
| |
1.08
|
(0.46-2.53)
| |
1.30
|
(0.57-2.97)
| |
HIV exposure category
| | |
0.09
| | |
0.99
| | |
0.01
|
Heterosexual
|
1.00
| | |
1.00
| | |
1.00
| | |
Homosexual/Bisexual
|
1.33
|
(0.96-1.85)
| |
1.05
|
(0.66-1.66)
| |
1.67
|
(1.06-2.63)
| |
IDU (Active+Former)
|
0.85
|
(0.60-1.19)
| |
1.00
|
(0.61-1.64)
| |
0.79
|
(0.50-1.24)
| |
Other/Unknown
|
0.92
|
(0.57-1.47)
| |
1.04
|
(0.57-1.88)
| |
0.74
|
(0.35-1.55)
| |
Clinical and laboratory data at treatment change
| | | | | | | | | |
Clinical AIDS
| | |
0.81
| | |
0.12
| | |
0.24
|
No
|
1.00
| | |
1.00
| | |
1.00
| | |
Yes
|
0.96
|
(0.72-1.29)
| |
0.71
|
(0.45-1.10)
| |
1.25
|
(0.86-1.81)
| |
CD4 cell count (cells/ml)
| | |
0.62
| | |
0.65
| | |
0.65
|
< 200
|
1.00
| | |
1.00
| | |
1.00
| | |
200-349
|
0.89
|
(0.66-1.21)
| |
0.82
|
(0.54-1.25)
| |
0.97
|
(0.64-1.48)
| |
> = 350
|
1.02
|
(0.76-1.35)
| |
0.89
|
(0.60-1.32)
| |
1.15
|
(0.77-1.70)
| |
HIV RNA (log 10 copies/ml)
| | |
0.05
| | |
0.99
| | |
0.01
|
< 2
|
1.00
| | |
1.00
| | |
1.00
| | |
2-3
|
1.27
|
(0.87-1.83)
| |
1.05
|
(0.60-1.83)
| |
1.39
|
(0.86-2.26)
| |
> = 4
|
1.55
|
(1.07-2.23)
| |
1.02
|
(0.58-1.80)
| |
2.05
|
(1.28-3.28)
| |
Presence of hepatic comorbidities
| | |
0.96
| | |
0.05
| | |
0.05
|
No
|
1.00
| | |
1.00
| | |
1.00
| | |
Yes
|
1.01
|
(0.76-1.33)
| |
0.65
|
(0.43-0.99)
| |
1.44
|
(1.00-2.09)
| |
Presence of other
b
comorbidities
| | |
0.85
| | |
0.98
| | |
0.96
|
No
|
1.00
| | |
1.00
| | |
1.00
| | |
Yes
|
1.04
|
(0.71-1.52)
| |
0.99
|
(0.54-1.83)
| |
1.01
|
(0.62-1.64)
| |
Number of experienced drugs
| | |
< 0.001
| | |
< 0.001
| | |
< 0.001
|
Naive
|
1.00
| | |
1.00
| | |
1.00
| | |
3-4
|
1.06
|
(0.78-1.44)
| |
0.55
|
(0.35-0.87)
| |
2.49
|
(1.58-3.93)
| |
5-7
|
1.40
|
(0.91-2.15)
| |
0.57
|
(0.28-1.15)
| |
3.54
|
(1.99-6.30)
| |
> 8
|
3.71
|
(2.13-6.45)
| |
2.60
|
(1.08-6.28)
| |
7.07
|
(3.43-14.56)
| |
Number of failed drugs
| | |
0.002
| | |
0.94
| | |
< 0.001
|
0-2
|
1.00
| | |
1.00
| | |
1.00
| | |
3-4
|
1.42
|
(1.03-1.95)
| |
1.07
|
(0.62-1.83)
| |
1.57
|
(1.06-2.33)
| |
> 5
|
2.38
|
(1.47-3.86)
| |
1.17
|
(0.48-2.83)
| |
2.96
|
(1.67-5.23)
| |
Calendar year (1 year increase)
|
0.80
|
(0.76-0.84)
|
< 0.001
|
0.78
|
(0.73-0.85)
|
< 0.001
|
0.82
|
(0.76-0.88)
|
< 0.001
|
Likelihood Ratio test for significance of Random effect
| | |
< 0.001
| | |
< 0.001
| | |
0.001
|