Table 1 Patient and treatment characteristics associated with non-cure in Yunnan province, China (N = 841)
Characteristic | N(%) | non-cure (%) | RR | 95% CI | p-value |
|---|---|---|---|---|---|
Sex | Â | Â | Â | Â | 0.27 |
Male | 575 (68.4) | 37 (6.4) | 1 | Â | Â |
Female | 266 (31.6) | 12 (4.5) | 0.69 | 0.35 - 1.3 | Â |
Age (years) | Â | Â | Â | Â | 0.66 |
<30 | 285 (33.9) | 18 (6.3) | 1 | Â | Â |
≥30 | 556 (66.1) | 31 (5.6) | 0.88 | 0.48 - 1.6 |  |
Education level** | Â | Â | Â | Â | 0.01 |
No formal education or primary school only | 520 (62.6) | 38 (7.3) | 1 | Â | Â |
Secondary school or higher | 311 (37.4) | 10 (3.2) | 0.42 | 0.21 - 0.86 | Â |
Medical insurance | Â | Â | Â | Â | 0.02 |
No | 153 (18.2) | 15 (9.8) | 1 | Â | Â |
Yes | 688 (81.8) | 34 (4.9) | 0.48 | 0.32 - 0.90 | Â |
Income*,** | Â | Â | Â | Â | 0.11 |
Low | 314 (37.3) | 21 (6.7) | 1 | Â | Â |
Middle | 239 (28.4) | 18 (7.5) | 1.1 | 0.59 - 2.2 | Â |
High | 288 (34.3) | 10 (3.5) | 0.50 | 0.23 - 1.12 | Â |
Co-morbidity | Â | Â | Â | Â | 0.06 |
No | 755 (89.8) | 40 (5.3) | 1 | Â | Â |
Yes | 86 (10.2) | 9 (11.6) | 2.1 | 0.98 - 4.5 | Â |
Patient delay (days) | Â | Â | Â | Â | 0.02 |
<30 | 243 (28.9) | 7 (2.9) | 1 | Â | Â |
≥30 | 598 (71.1) | 42 (7.5) | 2.5 | 1.1 - 5.8 |  |
Directly observed treatment | Â | Â | Â | Â | 0.01 |
Yes, by health care staff | 108 (12.8) | 4 (3.7) | 1 | Â | Â |
Yes, shared by health care staff and family member | 85 (10.1) | 9 (10.6) | 3.1 | 0.9 - 10.4 | Â |
Yes, by family member | 415 (49.3) | 15 (1.8) | 0.98 | 0.32 - 3.0 | Â |
No | 233 (27.7) | 21 (9.0) | 2.6 | 0.86 - 7.7 | Â |
Sputum smear status before treatment | Â | Â | Â | Â | 0.03 |
≤2+ | 503 (59.8) | 22 (4.4) | 1 |  |  |
>2+ | 338 (40.2) | 27 (8.0) | 1.9 | 1.1 - 3.4 | Â |
Sputum smear result after 2 months of treatment | Â | Â | Â | Â | 0.01 |
Negative | 726 (86.3) | 21 (2.9) | 1 | Â | Â |
Positive | 98 (11.7) | 11 (11.1) | 4.2 | 2.0 - 9.1 | Â |
Without test | 17 (2.0) | 17 (100) | 34.8 | 24.7 - 48.6# | Â |
Adverse events** | Â | Â | Â | Â | 0.06 |
No | 539 (65.8) | 22 (4.1) | 1 | Â | Â |
Yes, did not require hospitalization | 262 (32.0) | 10 (3.8) | 0.93 | 0.44 - 2.0 | Â |
Yes, required hospitalization | 18 (2.2) | 3 (16.7) | 4.7 | 1.3 - 17.4 | Â |
Interruption of treatment | Â | Â | Â | Â | 0.17 |
No | 686 (81.6) | 39 (5.7) | 1 | Â | Â |
Yes, during intensive phase | 28 (3.3) | 3 (10.7) | 2.0 | 0.58 - 6.9 | Â |
Yes, during continued phase | 96 (11.4) | 3 (3.1) | 0.54 | 0.16 - 1.8 | Â |
Yes, during intensive and continuation phase | 31 (3.7) | 4 (12.9) | 2.5 | 0.82 - 7.4 | Â |
Maximum number of missed doses in a row** | Â | Â | Â | Â | 0.09 |
0 | 682 (81.6) | 35 (5.1) | 1 | Â | Â |
1-7 | 102(12.2) | 3 (2.9) | 0.56 | 0.17 - 1.9 | Â |
>7 | 52 (6.2) | 6 (11.5) | 2.4 | 0.97 - 6.0 | Â |
Taking drugs according to guideline | Â | Â | Â | Â | < 0.001 |
Yes | 638 (75.9) | 19 (3.0) | 1 | Â | Â |
No | 203 (24.1) | 30 (14.8) | 5.7 | 3.1 - 10.3 | Â |
Patient knows that during treatment he/she should go to CDC for medical check-ups** | Â | Â | Â | Â | < 0.001 |
Yes | 752 (91.0) | 22 (2.9) | 1 | Â | Â |
No | 74 (9.0) | 14 (18.9) | 7.7 | 3.8 - 15.9 | Â |
Patient knows the duration of TB treatment | Â | Â | Â | Â | 0.001 |
Yes | 518 (61.6) | 19 (3.7) | 1 | Â | Â |
No | 323 (38.4) | 30 (9.3) | 2.7 | 1.5 - 4.9 | Â |
Patient agrees with the need for treatment observation** | Â | Â | Â | Â | 0.06 |
Yes | 209 (25.3) | 4 (1.9) | 1 | Â | Â |
No | 616 (74.7) | 31 (5.0) | 2.7 | 0.95 - 7.8 | Â |
Family attitude** | Â | Â | Â | Â | 0.07 |
More supportive than usual | 339 (40.3) | 9 (2.7) | 1 | Â | Â |
No change or less supportive than usual | 502 (59.7) | 40 (8.0) | 2.1 | 0.95 - 4.5 | Â |